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| 1st(1st leg) | Athletic Bilbao | - | Villarreal CF | 3:2 (0:2) | ||
| 2nd (2nd leg) | Villarreal CF | - | Athletic Bilbao | 0:1 (0:1) | ||
| 1st(1st leg): 06/01/2016 11:00 | 2nd (2nd leg): 13/01/2016 19:30 | Winner: Athletic Bilbao | ||||
| 1st(1st leg) | Valencia CF | - | Granada CF | 4:0 (2:0) | ||
| 2nd (2nd leg) | Granada CF | - | Valencia CF | 0:3 (0:1) | ||
| 1st(1st leg): 06/01/2016 15:00 | 2nd (2nd leg): 14/01/2016 19:00 | Winner: Valencia CF | ||||
| 1st(1st leg) | CD Mirandés | - | Deportivo La Coruña | 1:1 (1:0) | ||
| 2nd (2nd leg) | Deportivo La Coruña | - | CD Mirandés | 0:3 (0:1) | ||
| 1st(1st leg): 06/01/2016 15:00 | 2nd (2nd leg): 12/01/2016 19:30 | Winner: CD Mirandés | ||||
| 1st(1st leg) | Real Betis | - | Sevilla FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | Sevilla FC | - | Real Betis | 4:0 (2:0) | ||
| 1st(1st leg): 06/01/2016 17:15 | 2nd (2nd leg): 12/01/2016 19:30 | Winner: Sevilla FC | ||||
| 1st(1st leg) | FC Barcelona | - | Espanyol Barcelona | 4:1 (2:1) | ||
| 2nd (2nd leg) | Espanyol Barcelona | - | FC Barcelona | 0:2 (0:1) | ||
| 1st(1st leg): 06/01/2016 19:30 | 2nd (2nd leg): 13/01/2016 20:00 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Rayo Vallecano | - | Atlético Madrid | 1:1 (1:0) | ||
| 2nd (2nd leg) | Atlético Madrid | - | Rayo Vallecano | 3:0 (1:0) | ||
| 1st(1st leg): 06/01/2016 21:05 | 2nd (2nd leg): 14/01/2016 19:30 | Winner: Atlético Madrid | ||||
| 1st(1st leg) | Cádiz CF | - | RC Celta | 0:3 (0:1) | ||
| 2nd (2nd leg) | RC Celta | - | Cádiz CF | 2:0 (1:0) | ||
| 1st(1st leg): 07/01/2016 19:30 | 2nd (2nd leg): 13/01/2016 19:30 | Winner: RC Celta | ||||
| 1st(1st leg) | SD Eibar | - | UD Las Palmas | 2:3 (2:1) | ||
| 2nd (2nd leg) | UD Las Palmas | - | SD Eibar | 3:2 (1:0) | ||
| 1st(1st leg): 07/01/2016 19:30 | 2nd (2nd leg): 13/01/2016 20:00 | Winner: UD Las Palmas | ||||
