1st(1st leg) Atlético Madrid - FC Barcelona 1:3 (0:1)
2nd (2nd leg) FC Barcelona - Atlético Madrid 2:1 (1:1)
1st(1st leg): 06/01/2009 19:00 2nd (2nd leg): 14/01/2009 21:00 Winner: FC Barcelona
1st(1st leg) Polideportivo Ejido - Espanyol Barcelona 3:2 (0:1)
2nd (2nd leg) Espanyol Barcelona - Polideportivo Ejido 1:0 (1:0)
1st(1st leg): 07/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: Espanyol Barcelona
1st(1st leg) Racing Santander - Valencia CF 1:1 (0:1)
2nd (2nd leg) Valencia CF - Racing Santander 3:1 (1:1, 1:1, 3:1) aet
1st(1st leg): 07/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: Valencia CF
1st(1st leg) Sporting Gijón - Real Valladolid 3:1 (3:0)
2nd (2nd leg) Real Valladolid - Sporting Gijón 2:1 (1:0)
1st(1st leg): 07/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: Sporting Gijón
1st(1st leg) Real Unión - Real Betis 0:1 (0:1)
2nd (2nd leg) Real Betis - Real Unión 1:0 (1:0)
1st(1st leg): 07/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: Real Betis
1st(1st leg) Sevilla FC - Deportivo La Coruña 2:1 (2:0)
2nd (2nd leg) Deportivo La Coruña - Sevilla FC 0:3 (0:3)
1st(1st leg): 07/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: Sevilla FC
1st(1st leg) CA Osasuna - Athletic Club 1:1 (0:0)
2nd (2nd leg) Athletic Club - CA Osasuna 2:0 (2:0)
1st(1st leg): 08/01/2009 20:00 2nd (2nd leg): 15/01/2009 19:00 Winner: Athletic Club
1st(1st leg) RCD Mallorca - UD Almería 3:1 (2:1)
2nd (2nd leg) UD Almería - RCD Mallorca 1:1 (1:1)
1st(1st leg): 08/01/2009 20:00 2nd (2nd leg): 14/01/2009 19:00 Winner: RCD Mallorca