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| 19/03/2021 | 18:00 | Lincoln City | - | Watford FC | 2:3 (2:1, 2:2) aet | |
| 20/03/2021 | 12:00 | Blackburn Rovers | - | Arsenal FC | 1:4 (0:3) | |
| 22/03/2021 | 14:00 | Norwich City | - | West Ham United | 0:5 (0:3) | |
| 19:00 | Fleetwood Town | - | Bristol City | 2:4 (0:0, 1:1, 1:1) pso | ||
| 23/03/2021 | 19:00 | Exeter City | - | Leicester City | 1:2 (0:0, 0:0) aet | |
| 19:00 | Southampton FC | - | Burton Albion | 0:1 (0:0) | ||
| 24/03/2021 | 19:00 | Aston Villa | - | Brighton & Hove Albion | 3:0 (0:0) | |
| 27/03/2021 | 14:00 | Ipswich Town | - | Swindon Town | 3:1 (1:1) | |
| 31/03/2021 | 18:00 | AFC Wimbledon | - | Tottenham Hotspur | 0:3 (0:0, 0:0) aet | |
| 19:00 | West Bromwich Albion | - | Cardiff City | 2:1 (2:0) | ||
| 02/04/2021 | 11:00 | Swansea City | - | Middlesbrough FC | 0:1 (0:0) | |
| 12:30 | Chelsea FC | - | AFC Fylde | 2:0 (0:0) | ||
| 03/04/2021 | 13:00 | Peterborough United | - | Sheffield United | 0:2 (0:1) | |
| 14:00 | Manchester City | - | Everton FC | 0:1 (0:0) | ||
| 15:00 | Newcastle United | - | Leeds United | 4:1 (3:1) | ||
| 15:00 | Manchester United | - | Liverpool FC | 0:1 (0:1) |
