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| 22/09/2015 | 19:45 | Middlesbrough FC | - | Wolverhampton Wanderers | 3:0 (1:0) | |
| 19:45 | Hull City | - | Swansea City | 1:0 (1:0) | ||
| 19:45 | Leicester City | - | West Ham United | 2:1 (1:1, 1:1) aet | ||
| 19:45 | Aston Villa | - | Birmingham City | 1:0 (0:0) | ||
| 19:45 | Fulham FC | - | Stoke City | 0:1 (0:1) | ||
| 19:45 | Sunderland AFC | - | Manchester City | 1:4 (0:4) | ||
| 19:45 | Preston North End | - | AFC Bournemouth | 2:3 (0:1, 1:1, 2:2) pso | ||
| 20:00 | Reading FC | - | Everton FC | 1:2 (1:0) | ||
| 23/09/2015 | 19:45 | Norwich City | - | West Bromwich Albion | 3:0 (0:0) | |
| 19:45 | Tottenham Hotspur | - | Arsenal FC | 1:2 (0:1) | ||
| 19:45 | Crystal Palace | - | Charlton Athletic | 4:1 (0:0) | ||
| 19:45 | Newcastle United | - | Sheffield Wednesday | 0:1 (0:0) | ||
| 19:45 | Walsall FC | - | Chelsea FC | 1:4 (1:2) | ||
| 19:45 | Milton Keynes Dons | - | Southampton FC | 0:6 (0:3) | ||
| 20:00 | Manchester United | - | Ipswich Town | 3:0 (1:0) | ||
| 20:00 | Liverpool FC | - | Carlisle United | 3:2 (1:1, 1:1, 1:1) pso |
