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| 1st(1st leg) | Universidad Católica | - | Deportivo Cuenca | 3:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Cuenca | - | Universidad Católica | 0:2 (0:1) | ||
| 1st(1st leg): 02/09/2022 18:30 | 2nd (2nd leg): 10/09/2022 19:00 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Macará | - | Independiente del Valle | 1:0 (0:0) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Macará | 3:2 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 03/09/2022 18:00 | 2nd (2nd leg): 10/09/2022 18:00 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Manta FC | - | Olmedo | 1:1 (0:1) | ||
| 2nd (2nd leg) | Olmedo | - | Manta FC | 4:3 (1:0, 1:1, 1:1) pso | ||
| 1st(1st leg): 03/09/2022 18:15 | 2nd (2nd leg): 11/09/2022 18:00 | Winner: Olmedo | ||||
| 1st(1st leg) | Atlético Santo Domingo | - | LDU Quito | 1:0 (1:0) | ||
| 2nd (2nd leg) | LDU Quito | - | Atlético Santo Domingo | 3:1 (2:0) | ||
| 1st(1st leg): 04/09/2022 19:00 | 2nd (2nd leg): 10/09/2022 20:00 | Winner: LDU Quito | ||||
