 |
 |
|
| 1st(1st leg) | Orense SC | - | Universidad Católica | 1:0 (0:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | Orense SC | 3:1 (1:1) | ||
| 1st(1st leg): 19/08/2022 19:30 | 2nd (2nd leg): 26/08/2022 15:00 | Winner: Universidad Católica | ||||
| 1st(1st leg) | Chacaritas FC | - | Deportivo Cuenca | 2:1 (2:0) | ||
| 2nd (2nd leg) | Deportivo Cuenca | - | Chacaritas FC | 3:1 (0:1) | ||
| 1st(1st leg): 19/08/2022 21:00 | 2nd (2nd leg): 28/08/2022 16:00 | Winner: Deportivo Cuenca | ||||
| 1st(1st leg) | Manta FC | - | Emelec | 3:1 (1:0) | ||
| 2nd (2nd leg) | Emelec | - | Manta FC | 2:1 (0:0) | ||
| 1st(1st leg): 19/08/2022 21:15 | 2nd (2nd leg): 27/08/2022 19:00 | Winner: Manta FC | ||||
| 1st(1st leg) | LDU Quito | - | Aucas | 3:2 (1:0) | ||
| 2nd (2nd leg) | Aucas | - | LDU Quito | 1:1 (0:0) | ||
| 1st(1st leg): 20/08/2022 17:00 | 2nd (2nd leg): 27/08/2022 16:00 | Winner: LDU Quito | ||||
| 1st(1st leg) | Mushuc Runa | - | Independiente del Valle | 1:2 (1:1) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Mushuc Runa | 3:1 (1:1) | ||
| 1st(1st leg): 20/08/2022 17:45 | 2nd (2nd leg): 27/08/2022 18:15 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Barcelona | - | Olmedo | 0:3 (0:2) | ||
| 2nd (2nd leg) | Olmedo | - | Barcelona | 1:0 (1:0) | ||
| 1st(1st leg): 20/08/2022 18:00 | 2nd (2nd leg): 28/08/2022 20:15 | Winner: Olmedo | ||||
| 1st(1st leg) | Atlético Santo Domingo | - | El Nacional | 3:0 (1:0) | ||
| 2nd (2nd leg) | El Nacional | - | Atlético Santo Domingo | 1:3 (1:1) | ||
| 1st(1st leg): 21/08/2022 19:00 | 2nd (2nd leg): 27/08/2022 20:00 | Winner: Atlético Santo Domingo | ||||
| 1st(1st leg) | Macará | - | Guayaquil City | 3:1 (2:0) | ||
| 2nd (2nd leg) | Guayaquil City | - | Macará | 2:4 (1:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 25/08/2022 19:00 | 2nd (2nd leg): 29/08/2022 17:00 | Winner: Macará | ||||
