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| 14/09/2022 | 01:00 | El Nacional | - | Imbabura | 5:0 (1:0) | |
| 15/09/2022 | 01:00 | Búhos ULVR | - | América de Quito | 0:0 (0:0) | |
| 01:30 | Libertad de Loja | - | Chacaritas FC | 1:0 (0:0) | ||
| 21:00 | Independiente Juniors | - | Olmedo | 1:0 (0:0) | ||
| 16/09/2022 | 01:00 | Manta | - | Atlético Santo Domingo | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
El Nacional | 27 | 12 | 7 | 8 | 36:27 | 9 | 43 |
| 2 |
|
Independiente Juniors | 27 | 12 | 7 | 8 | 33:25 | 8 | 43 |
| 3 |
|
América de Quito | 27 | 11 | 8 | 8 | 32:25 | 7 | 41 |
| 4 |
|
Libertad de Loja | 27 | 11 | 8 | 8 | 32:30 | 2 | 41 |
| 5 |
|
Chacaritas FC | 27 | 10 | 9 | 8 | 24:25 | -1 | 39 |
| 6 |
|
Imbabura | 27 | 10 | 6 | 11 | 40:40 | 0 | 36 |
| 7 |
|
Búhos ULVR | 27 | 9 | 9 | 9 | 28:28 | 0 | 36 |
| 8 |
|
Atlético Santo Domingo | 27 | 6 | 10 | 11 | 22:25 | -3 | 28 |
| 9 |
|
Manta | 27 | 6 | 9 | 12 | 18:31 | -13 | 27 |
| 10 |
|
Olmedo | 27 | 6 | 11 | 10 | 23:32 | -9 | 26 |
| Promotion | |
| Relegation |
