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| 22/09/2021 | 01:00 | Atlético Porteño | - | El Nacional | 1:1 (0:1) | |
| 19:30 | Liga de Portoviejo | - | Atlético Santo Domingo | 3:3 (3:0) | ||
| 21:00 | América de Quito | - | Gualaceo SC | 1:1 (0:1) | ||
| 21:00 | Chacaritas FC | - | Guayaquil SC | 4:1 (2:1) | ||
| 24/09/2021 | 01:00 | Cumbayá | - | Independiente Juniors | 2:1 (2:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cumbayá | 33 | 19 | 7 | 7 | 42:29 | 13 | 64 |
| 2 |
|
Gualaceo SC | 33 | 15 | 9 | 9 | 42:27 | 15 | 54 |
| 3 |
|
El Nacional | 33 | 15 | 9 | 9 | 43:32 | 11 | 54 |
| 4 |
|
América de Quito | 33 | 10 | 15 | 8 | 38:29 | 9 | 45 |
| 5 |
|
Chacaritas FC | 33 | 11 | 12 | 10 | 31:31 | 0 | 45 |
| 6 |
|
Independiente Juniors | 33 | 11 | 8 | 14 | 41:41 | 0 | 41 |
| 7 |
|
Atlético Santo Domingo | 33 | 10 | 10 | 13 | 35:41 | -6 | 40 |
| 8 |
|
Guayaquil SC | 33 | 12 | 4 | 17 | 35:49 | -14 | 40 |
| 9 |
|
Liga de Portoviejo | 33 | 8 | 10 | 15 | 38:47 | -9 | 34 |
| 10 |
|
Atlético Porteño | 33 | 9 | 6 | 18 | 38:57 | -19 | 33 |
| Promotion | |
| Relegation |
