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| 08/09/2021 | 01:00 | Atlético Porteño | - | Gualaceo SC | 0:1 (0:1) | |
| 21:00 | América de Quito | - | Atlético Santo Domingo | 1:1 (0:1) | ||
| 21:00 | Chacaritas FC | - | El Nacional | 1:1 (0:1) | ||
| 21:00 | Liga de Portoviejo | - | Independiente Juniors | 0:1 (0:1) | ||
| 09/09/2021 | 01:00 | Cumbayá | - | Guayaquil SC | 1:0 (0:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cumbayá | 31 | 18 | 7 | 6 | 39:25 | 14 | 61 |
| 2 |
|
El Nacional | 31 | 15 | 8 | 8 | 41:27 | 14 | 53 |
| 3 |
|
Gualaceo SC | 31 | 14 | 8 | 9 | 38:25 | 13 | 50 |
| 4 |
|
Chacaritas FC | 31 | 10 | 12 | 9 | 27:28 | -1 | 42 |
| 5 |
|
América de Quito | 31 | 9 | 14 | 8 | 33:27 | 6 | 41 |
| 6 |
|
Independiente Juniors | 31 | 10 | 8 | 13 | 38:39 | -1 | 38 |
| 7 |
|
Guayaquil SC | 31 | 11 | 4 | 16 | 32:45 | -13 | 37 |
| 8 |
|
Atlético Santo Domingo | 31 | 9 | 9 | 13 | 30:38 | -8 | 36 |
| 9 |
|
Liga de Portoviejo | 31 | 8 | 9 | 14 | 35:42 | -7 | 33 |
| 10 |
|
Atlético Porteño | 31 | 9 | 5 | 17 | 37:54 | -17 | 32 |
| Promotion | |
| Relegation |
