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| 1st(1st leg) | Mineros SC | - | Barcelona | 1:1 (0:1) | ||
| 2nd (2nd leg) | Barcelona | - | Mineros SC | 2:0 (2:0) | ||
| 1st(1st leg): 24/04/2019 18:30 | 2nd (2nd leg): 17/05/2019 01:30 | Winner: Barcelona | ||||
| 1st(1st leg) | América de Quito | - | Liga de Portoviejo | 4:0 (3:0) | ||
| 2nd (2nd leg) | Liga de Portoviejo | - | América de Quito | 2:2 (1:1) | ||
| 1st(1st leg): 24/04/2019 21:00 | 2nd (2nd leg): 29/05/2019 18:00 | Winner: América de Quito | ||||
| 1st(1st leg) | FC Insutec | - | Delfín SC | 1:2 (1:1) | ||
| 2nd (2nd leg) | Delfín SC | - | FC Insutec | 0:0 (0:0) | ||
| 1st(1st leg): 24/04/2019 23:45 | 2nd (2nd leg): 23/05/2019 01:30 | Winner: Delfín SC | ||||
| 1st(1st leg) | Aucas | - | Toreros FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Toreros FC | - | Aucas | 0:2 (0:1) | ||
| 1st(1st leg): 25/04/2019 02:00 | 2nd (2nd leg): 30/05/2019 01:00 | Winner: Aucas | ||||
| 1st(1st leg) | Atlético Porteño | - | Macará | 1:2 (0:1) | ||
| 2nd (2nd leg) | Macará | - | Atlético Porteño | 3:1 (1:1) | ||
| 1st(1st leg): 25/04/2019 21:30 | 2nd (2nd leg): 15/05/2019 23:15 | Winner: Macará | ||||
| 1st(1st leg) | Guayaquil City | - | Clan Juvenil | 6:1 (5:1) | ||
| 2nd (2nd leg) | Clan Juvenil | - | Guayaquil City | 2:1 (0:0) | ||
| 1st(1st leg): 26/04/2019 00:00 | 2nd (2nd leg): 16/05/2019 21:00 | Winner: Guayaquil City | ||||
| 1st(1st leg) | Anaconda FC | - | El Nacional | 1:1 (0:0) | ||
| 2nd (2nd leg) | El Nacional | - | Anaconda FC | 4:0 (1:0) | ||
| 1st(1st leg): 30/04/2019 21:00 | 2nd (2nd leg): 28/05/2019 18:30 | Winner: El Nacional | ||||
| 1st(1st leg) | Independiente del Valle | - | Orense SC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Orense SC | - | Independiente del Valle | 0:0 (0:0) | ||
| 1st(1st leg): 01/05/2019 00:00 | 2nd (2nd leg): 14/05/2019 21:00 | Winner: Orense SC | ||||
| 1st(1st leg) | Emelec | - | Puerto Quito | 2:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Santo Domingo | - | Emelec | 0:2 (0:1) | ||
| 1st(1st leg): 01/05/2019 23:15 | 2nd (2nd leg): 15/05/2019 21:00 | Winner: Emelec | ||||
| 1st(1st leg) | LDU Quito | - | Gloria | 5:0 (1:0) | ||
| 2nd (2nd leg) | Gloria | - | LDU Quito | 0:0 (0:0) | ||
| 1st(1st leg): 02/05/2019 01:30 | 2nd (2nd leg): 16/05/2019 02:00 | Winner: LDU Quito | ||||
| 1st(1st leg) | Santa Rita | - | Fuerza Amarilla | 1:0 (0:0) | ||
| 2nd (2nd leg) | Fuerza Amarilla | - | Santa Rita | 1:3 (1:2) | ||
| 1st(1st leg): 02/05/2019 22:00 | 2nd (2nd leg): 29/05/2019 21:00 | Winner: Santa Rita | ||||
| 1st(1st leg) | Gualaceo SC | - | Deportivo Cuenca | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Cuenca | - | Gualaceo SC | 1:0 (1:0) | ||
| 1st(1st leg): 03/05/2019 01:30 | 2nd (2nd leg): 15/05/2019 02:15 | Winner: Deportivo Cuenca | ||||
| 1st(1st leg) | Independiente Juniors | - | Universidad Catolica | 2:0 (1:0) | ||
| 2nd (2nd leg) | Universidad Catolica | - | Independiente Juniors | 1:1 (1:1) | ||
| 1st(1st leg): 07/05/2019 22:00 | 2nd (2nd leg): 19/06/2019 22:00 | Winner: Independiente Juniors | ||||
| 1st(1st leg) | Olmedo | - | Alianza de Guano | 1:0 (0:0) | ||
| 2nd (2nd leg) | Alianza de Guano | - | Olmedo | 3:1 (1:0) | ||
| 1st(1st leg): 08/05/2019 01:00 | 2nd (2nd leg): 28/05/2019 21:30 | Winner: Alianza de Guano | ||||
| 1st(1st leg) | Manta | - | Mushuc Runa | 0:2 (0:1) | ||
| 2nd (2nd leg) | Mushuc Runa | - | Manta | 4:0 (1:0) | ||
| 1st(1st leg): 08/05/2019 21:00 | 2nd (2nd leg): 22/05/2019 18:00 | Winner: Mushuc Runa | ||||
| 1st(1st leg) | Técnico Universitario | - | Liga de Loja | 3:0 (1:0) | ||
| 2nd (2nd leg) | Liga de Loja | - | Técnico Universitario | 1:2 (0:2) | ||
| 1st(1st leg): 10/05/2019 02:00 | 2nd (2nd leg): 31/05/2019 01:30 | Winner: Técnico Universitario | ||||
