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| 1st(1st leg) | Everest | - | FC Insutec | 0:3 | ||
| 2nd (2nd leg) | FC Insutec | - | Everest | 3:2 | ||
| 1st(1st leg): 10/11/2018 17:00 | 2nd (2nd leg): 18/11/2018 21:00 | Winner: FC Insutec | ||||
| 1st(1st leg) | Espoli | - | Anaconda FC | 2:0 | ||
| 2nd (2nd leg) | Anaconda FC | - | Espoli | 2:0 | ||
| 1st(1st leg): 10/11/2018 18:00 | 2nd (2nd leg): 18/11/2018 19:00 | |||||
| 1st(1st leg) | Alianza de Guano | - | Morona | 2:0 | ||
| 2nd (2nd leg) | Morona | - | Alianza de Guano | 1:4 | ||
| 1st(1st leg): 10/11/2018 18:30 | 2nd (2nd leg): 18/11/2018 21:15 | Winner: Alianza de Guano | ||||
| 1st(1st leg) | Mineros SC | - | Spartak Macas | 2:0 | ||
| 2nd (2nd leg) | Spartak Macas | - | Mineros SC | 0:2 | ||
| 1st(1st leg): 10/11/2018 19:00 | 2nd (2nd leg): 18/11/2018 23:30 | Winner: Mineros SC | ||||
| 1st(1st leg) | Águilas | - | Brasilia | 0:2 | ||
| 2nd (2nd leg) | Brasilia | - | Águilas | 1:1 | ||
| 1st(1st leg): 10/11/2018 21:00 | 2nd (2nd leg): 17/11/2018 18:30 | Winner: Brasilia | ||||
| 1st(1st leg) | Dunamis TCE | - | Chicos Malos | 3:1 | ||
| 2nd (2nd leg) | Chicos Malos | - | Dunamis TCE | 2:1 | ||
| 1st(1st leg): 10/11/2018 21:00 | 2nd (2nd leg): 17/11/2018 17:00 | Winner: Dunamis TCE | ||||
| 1st(1st leg) | Valle Catamayo | - | Gloria | 1:9 | ||
| 2nd (2nd leg) | Gloria | - | Valle Catamayo | 3:1 | ||
| 1st(1st leg): 10/11/2018 22:00 | 2nd (2nd leg): 18/11/2018 16:00 | Winner: Gloria | ||||
| 1st(1st leg) | San Francisco de Azogues | - | Audaz Octubrino | 4:3 | ||
| 2nd (2nd leg) | Audaz Octubrino | - | San Francisco de Azogues | 1:0 | ||
| 1st(1st leg): 11/11/2018 17:30 | 2nd (2nd leg): 16/11/2018 02:00 | Winner: Audaz Octubrino | ||||
| 1st(1st leg) | América de Ambato | - | Deportivo Quito | 2:1 | ||
| 2nd (2nd leg) | Deportivo Quito | - | América de Ambato | 1:0 | ||
| 1st(1st leg): 11/11/2018 18:30 | 2nd (2nd leg): 18/11/2018 18:00 | Winner: Deportivo Quito | ||||
| 1st(1st leg) | San Pedro de Picoazá | - | Atlético Portoviejo | 0:2 | ||
| 2nd (2nd leg) | Atlético Portoviejo | - | San Pedro de Picoazá | 6:1 | ||
| 1st(1st leg): 14/11/2018 21:00 | 2nd (2nd leg): 21/11/2018 22:00 | Winner: Atlético Portoviejo | ||||
| 1st(1st leg) | Independiente Juniors | - | Imbabura | 3:0 | ||
| 2nd (2nd leg) | Imbabura | - | Independiente Juniors | 4:2 | ||
| 1st(1st leg): 14/11/2018 21:30 | 2nd (2nd leg): 21/11/2018 22:00 | Winner: Independiente Juniors | ||||
| 1st(1st leg) | Club Deportivo Duros del Balón | - | Toreros FC | 0:1 | ||
| 2nd (2nd leg) | Toreros FC | - | Club Deportivo Duros del Balón | 1:0 | ||
| 1st(1st leg): 14/11/2018 22:00 | 2nd (2nd leg): 21/11/2018 01:00 | Winner: Toreros FC | ||||
