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| 1st(1st leg) | Slavia Sofia | - | Feyenoord | 3:2 (1:1) | ||
| 2nd (2nd leg) | Feyenoord | - | Slavia Sofia | 4:0 (1:0) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: Feyenoord | ||||
| 1st(1st leg) | FC Carl Zeiss Jena | - | Newport County | 2:2 (1:1) | ||
| 2nd (2nd leg) | Newport County | - | FC Carl Zeiss Jena | 0:1 (0:1) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: FC Carl Zeiss Jena | ||||
| 1st(1st leg) | Fortuna Düsseldorf | - | SL Benfica | 2:2 (2:1) | ||
| 2nd (2nd leg) | SL Benfica | - | Fortuna Düsseldorf | 1:0 (0:0) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: SL Benfica | ||||
| 1st(1st leg) | West Ham United | - | Dinamo Tbilisi | 1:4 (0:2) | ||
| 2nd (2nd leg) | Dinamo Tbilisi | - | West Ham United | 0:1 (0:0) | ||
| 1st(1st leg): 04/03/1981 | 2nd (2nd leg): 18/03/1981 | Winner: Dinamo Tbilisi | ||||
