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| 1st(1st leg) | Vejle BK | - | Kolding IF | 5:1 (2:0) | ||
| 2nd (2nd leg) | Kolding IF | - | Vejle BK | 2:1 (1:0) | ||
| 1st(1st leg): 04/12/2021 17:00 | 2nd (2nd leg): 11/12/2021 17:00 | Winner: Vejle BK | ||||
| 1st(1st leg) | SønderjyskE | - | Hvidovre IF | 1:0 (0:0) | ||
| 2nd (2nd leg) | Hvidovre IF | - | SønderjyskE | 3:4 (2:0, 2:1, 3:2) pso | ||
| 1st(1st leg): 05/12/2021 11:30 | 2nd (2nd leg): 10/12/2021 17:00 | Winner: SønderjyskE | ||||
| 1st(1st leg) | Brøndby IF | - | FC Midtjylland | 0:2 (0:1) | ||
| 2nd (2nd leg) | FC Midtjylland | - | Brøndby IF | 1:2 (1:1) | ||
| 1st(1st leg): 05/12/2021 13:30 | 2nd (2nd leg): 12/12/2021 17:00 | Winner: FC Midtjylland | ||||
| 1st(1st leg) | Randers FC | - | Odense BK | 0:2 (0:2) | ||
| 2nd (2nd leg) | Odense BK | - | Randers FC | 1:2 (0:1) | ||
| 1st(1st leg): 05/12/2021 17:00 | 2nd (2nd leg): 12/12/2021 18:30 | Winner: Odense BK | ||||
