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| 1st(1st leg) | AE Paphos | - | Olympiakos Nikosia | 0:0 (0:0) | ||
| 2nd (2nd leg) | Olympiakos Nikosia | - | AE Paphos | 3:1 (1:1) | ||
| 1st(1st leg): 12/01/2011 14:00 | 2nd (2nd leg): 26/01/2011 16:00 | Winner: Olympiakos Nikosia | ||||
| 1st(1st leg) | AEL Limassol | - | Aris Limassol | 0:1 (0:1) | ||
| 2nd (2nd leg) | Aris Limassol | - | AEL Limassol | 0:0 (0:0) | ||
| 1st(1st leg): 12/01/2011 14:00 | 2nd (2nd leg): 26/01/2011 15:00 | Winner: Aris Limassol | ||||
| 1st(1st leg) | Doxa Katokopias | - | AEK Larnaca | 0:1 (0:1) | ||
| 2nd (2nd leg) | AEK Larnaca | - | Doxa Katokopias | 4:1 (1:1) | ||
| 1st(1st leg): 12/01/2011 14:00 | 2nd (2nd leg): 19/01/2011 14:00 | Winner: AEK Larnaca | ||||
| 1st(1st leg) | Ermis Aradippou | - | Ethnikos Achna | 0:1 (0:0) | ||
| 2nd (2nd leg) | Ethnikos Achna | - | Ermis Aradippou | 1:1 (0:1) | ||
| 1st(1st leg): 12/01/2011 14:00 | 2nd (2nd leg): 19/01/2011 16:00 | Winner: Ethnikos Achna | ||||
| 1st(1st leg) | APOEL Nikosia | - | Apollon Limassol | 1:1 (0:1) | ||
| 2nd (2nd leg) | Apollon Limassol | - | APOEL Nikosia | 2:0 (1:0) | ||
| 1st(1st leg): 12/01/2011 16:00 | 2nd (2nd leg): 19/01/2011 16:00 | Winner: Apollon Limassol | ||||
| 1st(1st leg) | Anorthosis Famagusta | - | APEP Pitsilias | 2:0 (1:0) | ||
| 2nd (2nd leg) | APEP Pitsilias | - | Anorthosis Famagusta | 0:1 (0:1) | ||
| 1st(1st leg): 12/01/2011 16:00 | 2nd (2nd leg): 02/02/2011 15:00 | Winner: Anorthosis Famagusta | ||||
| 1st(1st leg) | Omonia Nikosia | - | Atromitos Yeroskipou | 6:0 (1:0) | ||
| 2nd (2nd leg) | Atromitos Yeroskipou | - | Omonia Nikosia | 2:2 (1:2) | ||
| 1st(1st leg): 19/01/2011 14:00 | 2nd (2nd leg): 26/01/2011 14:00 | Winner: Omonia Nikosia | ||||
| 1st(1st leg) | Enosis Neon Paralimni | - | Alki Larnaca | 0:1 (0:1) | ||
| 2nd (2nd leg) | Alki Larnaca | - | Enosis Neon Paralimni | 4:3 (3:1) | ||
| 1st(1st leg): 26/01/2011 16:00 | 2nd (2nd leg): 16/02/2011 16:00 | Winner: Alki Larnaca | ||||
