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| 1st(1st leg) | Independiente del Valle | - | FBC Melgar | 3:0 (1:0) | ||
| 2nd (2nd leg) | FBC Melgar | - | Independiente del Valle | 0:3 (0:1) | ||
| 1st(1st leg): 01/09/2022 01:30 | 2nd (2nd leg): 08/09/2022 01:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Atlético Goianiense | - | São Paulo FC | 3:1 (1:1) | ||
| 2nd (2nd leg) | São Paulo FC | - | Atlético Goianiense | 4:2 (1:0, 2:0) pso | ||
| 1st(1st leg): 02/09/2022 01:30 | 2nd (2nd leg): 09/09/2022 01:30 | Winner: São Paulo FC | ||||
