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| 1st(1st leg) | Royal Pari | - | La Equidad | 1:2 (1:0) | ||
| 2nd (2nd leg) | La Equidad | - | Royal Pari | 2:1 (0:1) | ||
| 1st(1st leg): 10/07/2019 01:30 | 2nd (2nd leg): 17/07/2019 01:30 | Winner: La Equidad | ||||
| 1st(1st leg) | Caracas FC | - | Independiente del Valle | 0:0 (0:0) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Caracas FC | 2:0 (0:0) | ||
| 1st(1st leg): 10/07/2019 21:00 | 2nd (2nd leg): 18/07/2019 01:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Colón de Santa Fe | - | Argentinos Juniors | 0:1 (0:1) | ||
| 2nd (2nd leg) | Argentinos Juniors | - | Colón de Santa Fe | 3:4 (0:0, 0:1) pso | ||
| 1st(1st leg): 12/07/2019 01:30 | 2nd (2nd leg): 19/07/2019 01:30 | Winner: Colón de Santa Fe | ||||
| 1st(1st leg) | Zulia FC | - | Sporting Cristal | 1:0 (0:0) | ||
| 2nd (2nd leg) | Sporting Cristal | - | Zulia FC | 3:2 (0:1) | ||
| 1st(1st leg): 23/07/2019 21:00 | 2nd (2nd leg): 30/07/2019 23:15 | Winner: Zulia FC | ||||
| 1st(1st leg) | Peñarol | - | Fluminense RJ | 1:2 (0:1) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Peñarol | 3:1 (2:0) | ||
| 1st(1st leg): 24/07/2019 01:30 | 2nd (2nd leg): 31/07/2019 01:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Botafogo - RJ | - | Atlético Mineiro | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Botafogo - RJ | 2:0 (0:0) | ||
| 1st(1st leg): 25/07/2019 01:30 | 2nd (2nd leg): 01/08/2019 01:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Corinthians SP | - | Montevideo Wanderers | 2:0 (1:0) | ||
| 2nd (2nd leg) | Montevideo Wanderers | - | Corinthians SP | 1:2 (0:0) | ||
| 1st(1st leg): 26/07/2019 01:30 | 2nd (2nd leg): 02/08/2019 01:30 | Winner: Corinthians SP | ||||
| 1st(1st leg) | Independiente | - | Universidad Catolica | 1:0 (0:0) | ||
| 2nd (2nd leg) | Universidad Catolica | - | Independiente | 3:2 (1:0) | ||
| 1st(1st leg): 26/07/2019 01:30 | 2nd (2nd leg): 02/08/2019 01:30 | Winner: Independiente | ||||
