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| 1st(1st leg) | Deportivo La Guaira | - | Emelec | 4:2 (2:0) | ||
| 2nd (2nd leg) | Emelec | - | Deportivo La Guaira | 0:0 (0:0) | ||
| 1st(1st leg): 23/08/2016 23:15 | 2nd (2nd leg): 14/09/2016 22:00 | Winner: Deportivo La Guaira | ||||
| 1st(1st leg) | Banfield | - | San Lorenzo | 2:0 (2:0) | ||
| 2nd (2nd leg) | San Lorenzo | - | Banfield | 4:1 (4:1) | ||
| 1st(1st leg): 23/08/2016 23:15 | 2nd (2nd leg): 13/09/2016 23:15 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Blooming | - | Atlético Junior | 0:2 (0:1) | ||
| 2nd (2nd leg) | Atlético Junior | - | Blooming | 1:1 (1:0) | ||
| 1st(1st leg): 24/08/2016 01:45 | 2nd (2nd leg): 15/09/2016 01:45 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Real Garcilaso | - | Palestino | 2:2 (1:2) | ||
| 2nd (2nd leg) | Palestino | - | Real Garcilaso | 1:0 (0:0) | ||
| 1st(1st leg): 24/08/2016 21:00 | 2nd (2nd leg): 15/09/2016 23:15 | Winner: Palestino | ||||
| 1st(1st leg) | Bolívar | - | Atlético Nacional | 1:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Bolívar | 1:0 (0:0) | ||
| 1st(1st leg): 24/08/2016 23:15 | 2nd (2nd leg): 14/09/2016 01:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Cerro Porteño | - | Real Potosí | 6:0 (4:0) | ||
| 2nd (2nd leg) | Real Potosí | - | Cerro Porteño | 0:1 (0:0) | ||
| 1st(1st leg): 24/08/2016 23:15 | 2nd (2nd leg): 15/09/2016 23:30 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Santa Cruz - PE | - | Sport Recife - PE | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sport Recife - PE | - | Santa Cruz - PE | 0:1 (0:0) | ||
| 1st(1st leg): 25/08/2016 01:45 | 2nd (2nd leg): 01/09/2016 01:45 | Winner: Santa Cruz - PE | ||||
| 1st(1st leg) | Estudiantes | - | Belgrano de Córdoba | 1:0 (1:0) | ||
| 2nd (2nd leg) | Belgrano de Córdoba | - | Estudiantes | 2:0 (0:0) | ||
| 1st(1st leg): 25/08/2016 01:45 | 2nd (2nd leg): 16/09/2016 01:45 | Winner: Belgrano de Córdoba | ||||
| 1st(1st leg) | Figueirense - SC | - | Flamengo RJ | 4:2 (3:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Figueirense - SC | 3:1 (2:1) | ||
| 1st(1st leg): 25/08/2016 01:45 | 2nd (2nd leg): 01/09/2016 01:45 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Independiente Medellín | - | Sportivo Luqueño | 3:0 (1:0) | ||
| 2nd (2nd leg) | Sportivo Luqueño | - | Independiente Medellín | 2:0 (2:0) | ||
| 1st(1st leg): 25/08/2016 01:45 | 2nd (2nd leg): 16/09/2016 01:45 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Cuiabá - MT | - | Chapecoense | 1:0 (1:0) | ||
| 2nd (2nd leg) | Chapecoense | - | Cuiabá - MT | 3:1 (0:1) | ||
| 1st(1st leg): 25/08/2016 23:00 | 2nd (2nd leg): 01/09/2016 01:45 | Winner: Chapecoense | ||||
| 1st(1st leg) | Lanús | - | Independiente | 0:2 (0:0) | ||
| 2nd (2nd leg) | Independiente | - | Lanús | 1:0 (1:0) | ||
| 1st(1st leg): 25/08/2016 23:15 | 2nd (2nd leg): 14/09/2016 23:15 | Winner: Independiente | ||||
| 1st(1st leg) | Zamora FC | - | Montevideo Wanderers | 0:1 (0:0) | ||
| 2nd (2nd leg) | Montevideo Wanderers | - | Zamora FC | 1:0 (0:0) | ||
| 1st(1st leg): 26/08/2016 01:45 | 2nd (2nd leg): 14/09/2016 20:00 | Winner: Montevideo Wanderers | ||||
| 1st(1st leg) | Vitória - BA | - | Coritiba - PR | 2:1 (0:1) | ||
| 2nd (2nd leg) | Coritiba - PR | - | Vitória - BA | 1:0 (0:0) | ||
| 1st(1st leg): 26/08/2016 01:45 | 2nd (2nd leg): 31/08/2016 21:00 | Winner: Coritiba - PR | ||||
| 1st(1st leg) | Sol de América | - | Sport Huancayo | 1:0 (1:0) | ||
| 2nd (2nd leg) | Sport Huancayo | - | Sol de América | 1:1 (1:0) | ||
| 1st(1st leg): 26/08/2016 01:45 | 2nd (2nd leg): 15/09/2016 20:15 | Winner: Sol de América | ||||
