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| 1st(1st leg) | Deportivo Lara | - | Atlético Junior | 1:3 (1:1) | ||
| 2nd (2nd leg) | Atlético Junior | - | Deportivo Lara | 2:1 (1:0) | ||
| 1st(1st leg): 09/08/2016 23:00 | 2nd (2nd leg): 17/08/2016 03:00 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Sportivo Luqueño | - | Peñarol | 0:0 (0:0) | ||
| 2nd (2nd leg) | Peñarol | - | Sportivo Luqueño | 1:1 (0:0) | ||
| 1st(1st leg): 09/08/2016 23:15 | 2nd (2nd leg): 17/08/2016 00:30 | Winner: Sportivo Luqueño | ||||
| 1st(1st leg) | Fénix | - | Cerro Porteño | 1:0 (1:0) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Fénix | 2:0 (1:0) | ||
| 1st(1st leg): 10/08/2016 01:15 | 2nd (2nd leg): 18/08/2016 01:00 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Real Potosí | - | Universidad Católica | 3:1 (1:0) | ||
| 2nd (2nd leg) | Universidad Católica | - | Real Potosí | 1:1 (1:0) | ||
| 1st(1st leg): 10/08/2016 01:30 | 2nd (2nd leg): 18/08/2016 01:00 | Winner: Real Potosí | ||||
| 1st(1st leg) | Universitario de Deportes | - | Emelec | 0:3 (0:0) | ||
| 2nd (2nd leg) | Emelec | - | Universitario de Deportes | 3:1 (2:1) | ||
| 1st(1st leg): 10/08/2016 03:30 | 2nd (2nd leg): 17/08/2016 03:00 | Winner: Emelec | ||||
| 1st(1st leg) | Universidad de Concepción | - | Bolívar | 2:0 (0:0) | ||
| 2nd (2nd leg) | Bolívar | - | Universidad de Concepción | 3:0 (2:0) | ||
| 1st(1st leg): 10/08/2016 23:00 | 2nd (2nd leg): 16/08/2016 22:00 | Winner: Bolívar | ||||
| 1st(1st leg) | Sol de América | - | Jorge Wilstermann | 1:1 (0:0) | ||
| 2nd (2nd leg) | Jorge Wilstermann | - | Sol de América | 4:5 (0:0, 1:1) pso | ||
| 1st(1st leg): 11/08/2016 01:00 | 2nd (2nd leg): 18/08/2016 22:30 | Winner: Sol de América | ||||
| 1st(1st leg) | Montevideo Wanderers | - | O'Higgins | 0:0 (0:0) | ||
| 2nd (2nd leg) | O'Higgins | - | Montevideo Wanderers | 4:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 11/08/2016 01:00 | 2nd (2nd leg): 17/08/2016 00:30 | Winner: Montevideo Wanderers | ||||
| 1st(1st leg) | Barcelona | - | Zamora FC | 1:1 (0:0) | ||
| 2nd (2nd leg) | Zamora FC | - | Barcelona | 3:0 (0:1, 1:1) pso | ||
| 1st(1st leg): 11/08/2016 03:15 | 2nd (2nd leg): 18/08/2016 23:00 | Winner: Zamora FC | ||||
| 1st(1st leg) | Independiente Medellín | - | Universidad Catolica | 1:1 (1:0) | ||
| 2nd (2nd leg) | Universidad Catolica | - | Independiente Medellín | 0:1 (0:1) | ||
| 1st(1st leg): 11/08/2016 03:30 | 2nd (2nd leg): 17/08/2016 22:30 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Aucas | - | Real Garcilaso | 2:1 (2:1) | ||
| 2nd (2nd leg) | Real Garcilaso | - | Aucas | 1:0 (1:0) | ||
| 1st(1st leg): 11/08/2016 22:30 | 2nd (2nd leg): 18/08/2016 03:15 | Winner: Real Garcilaso | ||||
| 1st(1st leg) | Deportivo Anzoátegui | - | Sport Huancayo | 2:1 (1:1) | ||
| 2nd (2nd leg) | Sport Huancayo | - | Deportivo Anzoátegui | 1:0 (0:0) | ||
| 1st(1st leg): 11/08/2016 22:30 | 2nd (2nd leg): 18/08/2016 21:00 | Winner: Sport Huancayo | ||||
| 1st(1st leg) | Blooming | - | Plaza Colonia | 1:0 (1:0) | ||
| 2nd (2nd leg) | Plaza Colonia | - | Blooming | 1:4 (0:0, 1:0) pso | ||
| 1st(1st leg): 12/08/2016 00:00 | 2nd (2nd leg): 17/08/2016 22:30 | Winner: Blooming | ||||
| 1st(1st leg) | Palestino | - | Libertad | 1:0 (1:0) | ||
| 2nd (2nd leg) | Libertad | - | Palestino | 0:3 (0:0) | ||
| 1st(1st leg): 12/08/2016 00:45 | 2nd (2nd leg): 19/08/2016 01:30 | Winner: Palestino | ||||
| 1st(1st leg) | Deportes Tolima | - | Deportivo La Guaira | 0:0 (0:0) | ||
| 2nd (2nd leg) | Deportivo La Guaira | - | Deportes Tolima | 1:0 (1:0) | ||
| 1st(1st leg): 12/08/2016 02:15 | 2nd (2nd leg): 17/08/2016 22:30 | Winner: Deportivo La Guaira | ||||
| 1st(1st leg) | Deportivo Municipal | - | Atlético Nacional | 0:5 (0:1) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Deportivo Municipal | 1:0 (1:0) | ||
| 1st(1st leg): 12/08/2016 03:00 | 2nd (2nd leg): 18/08/2016 03:15 | Winner: Atlético Nacional | ||||
