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| 1st(1st leg) | Deportes Iquique | - | Santa Fe | 2:1 (1:1) | ||
| 2nd (2nd leg) | Santa Fe | - | Deportes Iquique | 1:2 (1:1, 2:1) pso | ||
| 1st(1st leg): 18/02/2025 22:00 | 2nd (2nd leg): 25/02/2025 22:00 | Winner: Deportes Iquique | ||||
| 1st(1st leg) | Alianza Lima | - | Boca Juniors | 1:0 (1:0) | ||
| 2nd (2nd leg) | Boca Juniors | - | Alianza Lima | 4:5 (1:1, 2:1) pso | ||
| 1st(1st leg): 19/02/2025 00:30 | 2nd (2nd leg): 26/02/2025 00:30 | Winner: Alianza Lima | ||||
| 1st(1st leg) | The Strongest | - | Bahia - BA | 1:1 (1:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | The Strongest | 3:0 (1:0) | ||
| 1st(1st leg): 19/02/2025 00:30 | 2nd (2nd leg): 26/02/2025 00:30 | Winner: Bahia - BA | ||||
| 1st(1st leg) | Boston River | - | Ñublense | 1:0 (0:0) | ||
| 2nd (2nd leg) | Ñublense | - | Boston River | 1:1 (1:0) | ||
| 1st(1st leg): 19/02/2025 22:00 | 2nd (2nd leg): 26/02/2025 22:00 | Winner: Boston River | ||||
| 1st(1st leg) | El Nacional | - | Barcelona | 0:1 (0:0) | ||
| 2nd (2nd leg) | Barcelona | - | El Nacional | 1:1 (0:1) | ||
| 1st(1st leg): 20/02/2025 00:30 | 2nd (2nd leg): 27/02/2025 00:30 | Winner: Barcelona | ||||
| 1st(1st leg) | Universidad Central | - | Corinthians SP | 1:1 (0:1) | ||
| 2nd (2nd leg) | Corinthians SP | - | Universidad Central | 3:2 (2:2) | ||
| 1st(1st leg): 20/02/2025 00:30 | 2nd (2nd leg): 27/02/2025 00:30 | Winner: Corinthians SP | ||||
| 1st(1st leg) | Monagas | - | Cerro Porteño | 0:4 (0:3) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Monagas | 3:1 (2:1) | ||
| 1st(1st leg): 20/02/2025 22:00 | 2nd (2nd leg): 27/02/2025 22:00 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | Deportes Tolima | - | FBC Melgar | 0:1 (0:1) | ||
| 2nd (2nd leg) | FBC Melgar | - | Deportes Tolima | 1:0 (0:0) | ||
| 1st(1st leg): 21/02/2025 00:30 | 2nd (2nd leg): 28/02/2025 00:30 | Winner: FBC Melgar | ||||
