 |
 |
|
|
| 1st(1st leg) | Club Nacional | - | Sporting Cristal | 2:0 (0:0) | ||
| 2nd (2nd leg) | Sporting Cristal | - | Club Nacional | 5:1 (0:0) | ||
| 1st(1st leg): 21/02/2023 22:00 | 2nd (2nd leg): 01/03/2023 00:00 | Winner: Sporting Cristal | ||||
| 1st(1st leg) | Curicó Unido | - | Cerro Porteño | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Curicó Unido | 1:0 (0:0) | ||
| 1st(1st leg): 22/02/2023 00:00 | 2nd (2nd leg): 28/02/2023 22:00 | Winner: Cerro Porteño | ||||
| 1st(1st leg) | El Nacional | - | Independiente Medellín | 2:2 (0:1) | ||
| 2nd (2nd leg) | Independiente Medellín | - | El Nacional | 2:1 (0:0) | ||
| 1st(1st leg): 22/02/2023 22:00 | 2nd (2nd leg): 02/03/2023 00:00 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Boston River | - | Huracán | 0:0 (0:0) | ||
| 2nd (2nd leg) | Huracán | - | Boston River | 1:0 (1:0) | ||
| 1st(1st leg): 23/02/2023 00:00 | 2nd (2nd leg): 01/03/2023 22:00 | Winner: Huracán | ||||
| 1st(1st leg) | Carabobo FC | - | Atlético Mineiro | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Carabobo FC | 3:1 (2:1) | ||
| 1st(1st leg): 23/02/2023 00:30 | 2nd (2nd leg): 02/03/2023 00:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | CD Magallanes | - | Always Ready | 3:0 (1:0) | ||
| 2nd (2nd leg) | Always Ready | - | CD Magallanes | 1:3 (0:1) | ||
| 1st(1st leg): 23/02/2023 22:00 | 2nd (2nd leg): 02/03/2023 22:00 | Winner: CD Magallanes | ||||
| 1st(1st leg) | Deportivo Maldonado | - | Fortaleza - CE | 0:0 (0:0) | ||
| 2nd (2nd leg) | Fortaleza - CE | - | Deportivo Maldonado | 4:0 (1:0) | ||
| 1st(1st leg): 24/02/2023 00:00 | 2nd (2nd leg): 03/03/2023 00:00 | Winner: Fortaleza - CE | ||||
| 1st(1st leg) | Universidad Catolica | - | Millonarios | 0:0 (0:0) | ||
| 2nd (2nd leg) | Millonarios | - | Universidad Catolica | 2:1 (0:1) | ||
| 1st(1st leg): 24/02/2023 00:00 | 2nd (2nd leg): 03/03/2023 00:00 | Winner: Millonarios | ||||
