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| 1st(1st leg) | São Paulo FC | - | Palmeiras | 1:1 (0:0) | ||
| 2nd (2nd leg) | Palmeiras | - | São Paulo FC | 3:0 (1:0) | ||
| 1st(1st leg): 11/08/2021 01:30 | 2nd (2nd leg): 18/08/2021 01:30 | Winner: Palmeiras | ||||
| 1st(1st leg) | Club Olimpia | - | Flamengo RJ | 1:4 (1:2) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Club Olimpia | 5:1 (2:1) | ||
| 1st(1st leg): 11/08/2021 23:15 | 2nd (2nd leg): 18/08/2021 23:15 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | River Plate | - | Atlético Mineiro | 0:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | River Plate | 3:0 (2:0) | ||
| 1st(1st leg): 12/08/2021 01:30 | 2nd (2nd leg): 19/08/2021 01:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Fluminense RJ | - | Barcelona | 2:2 (1:0) | ||
| 2nd (2nd leg) | Barcelona | - | Fluminense RJ | 1:1 (0:0) | ||
| 1st(1st leg): 13/08/2021 01:30 | 2nd (2nd leg): 20/08/2021 01:30 | Winner: Barcelona | ||||
