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| 1st(1st leg) | Athletico Paranaense | - | River Plate | 1:1 (0:0) | ||
| 2nd (2nd leg) | River Plate | - | Athletico Paranaense | 1:0 (0:0) | ||
| 1st(1st leg): 24/11/2020 22:15 | 2nd (2nd leg): 01/12/2020 22:15 | Winner: River Plate | ||||
| 1st(1st leg) | LDU Quito | - | Santos FC | 1:2 (1:1) | ||
| 2nd (2nd leg) | Santos FC | - | LDU Quito | 0:1 (0:0) | ||
| 1st(1st leg): 24/11/2020 22:15 | 2nd (2nd leg): 01/12/2020 22:15 | Winner: Santos FC | ||||
| 1st(1st leg) | Racing Club | - | Flamengo RJ | 1:1 (1:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Racing Club | 3:5 (0:0, 1:1) pso | ||
| 1st(1st leg): 25/11/2020 00:30 | 2nd (2nd leg): 02/12/2020 00:30 | Winner: Racing Club | ||||
| 1st(1st leg) | Independiente del Valle | - | Nacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Nacional | - | Independiente del Valle | 4:2 (0:0, 0:0) pso | ||
| 1st(1st leg): 25/11/2020 22:15 | 2nd (2nd leg): 02/12/2020 22:15 | Winner: Nacional | ||||
| 1st(1st leg) | Delfín SC | - | Palmeiras | 1:3 (0:2) | ||
| 2nd (2nd leg) | Palmeiras | - | Delfín SC | 5:0 (1:0) | ||
| 1st(1st leg): 25/11/2020 22:15 | 2nd (2nd leg): 02/12/2020 22:15 | Winner: Palmeiras | ||||
| 1st(1st leg) | Libertad | - | Jorge Wilstermann | 3:1 (0:0) | ||
| 2nd (2nd leg) | Jorge Wilstermann | - | Libertad | 0:2 (0:0) | ||
| 1st(1st leg): 26/11/2020 00:30 | 2nd (2nd leg): 03/12/2020 00:30 | Winner: Libertad | ||||
| 1st(1st leg) | Guaraní | - | Grêmio Porto Alegre | 0:2 (0:0) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Guaraní | 2:0 (1:0) | ||
| 1st(1st leg): 27/11/2020 00:30 | 2nd (2nd leg): 04/12/2020 00:30 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Internacional | - | Boca Juniors | 0:1 (0:0) | ||
| 2nd (2nd leg) | Boca Juniors | - | Internacional | 5:4 (0:0, 0:1) pso | ||
| 1st(1st leg): 03/12/2020 00:30 | 2nd (2nd leg): 10/12/2020 00:30 | Winner: Boca Juniors | ||||
