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| 1st(1st leg) | Danubio | - | Atlético Mineiro | 2:2 (1:1) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Danubio | 3:2 (3:1) | ||
| 1st(1st leg): 05/02/2019 21:15 | 2nd (2nd leg): 12/02/2019 21:15 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | FBC Melgar | - | Universidad de Chile | 1:0 (0:0) | ||
| 2nd (2nd leg) | Universidad de Chile | - | FBC Melgar | 0:0 (0:0) | ||
| 1st(1st leg): 05/02/2019 23:30 | 2nd (2nd leg): 13/02/2019 21:15 | Winner: FBC Melgar | ||||
| 1st(1st leg) | The Strongest | - | Libertad | 1:1 (0:0) | ||
| 2nd (2nd leg) | Libertad | - | The Strongest | 5:1 (1:1) | ||
| 1st(1st leg): 05/02/2019 23:30 | 2nd (2nd leg): 13/02/2019 21:15 | Winner: Libertad | ||||
| 1st(1st leg) | Delfín SC | - | Caracas FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Caracas FC | - | Delfín SC | 0:0 (0:0) | ||
| 1st(1st leg): 06/02/2019 21:15 | 2nd (2nd leg): 13/02/2019 23:30 | Winner: Caracas FC | ||||
| 1st(1st leg) | Defensor Sporting | - | Barcelona | 3:0 (0:0) dec. | ||
| 2nd (2nd leg) | Barcelona | - | Defensor Sporting | 1:0 (1:0) | ||
| 1st(1st leg): 06/02/2019 21:15 | 2nd (2nd leg): 12/02/2019 23:30 | Winner: Defensor Sporting | ||||
| 1st(1st leg) | Palestino | - | Independiente Medellín | 1:1 (0:0) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Palestino | 1:4 (1:1, 1:1) pso | ||
| 1st(1st leg): 06/02/2019 23:30 | 2nd (2nd leg): 12/02/2019 23:30 | Winner: Palestino | ||||
| 1st(1st leg) | Talleres de Córdoba | - | São Paulo FC | 2:0 (0:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Talleres de Córdoba | 0:0 (0:0) | ||
| 1st(1st leg): 06/02/2019 23:30 | 2nd (2nd leg): 13/02/2019 23:30 | Winner: Talleres de Córdoba | ||||
| 1st(1st leg) | Deportivo La Guaira | - | Atlético Nacional | 0:1 (0:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Deportivo La Guaira | 0:0 (0:0) | ||
| 1st(1st leg): 07/02/2019 23:30 | 2nd (2nd leg): 14/02/2019 23:30 | Winner: Atlético Nacional | ||||
