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| 1st(1st leg) | Estudiantes | - | Grêmio Porto Alegre | 2:1 (2:1) | ||
| 2nd (2nd leg) | Grêmio Porto Alegre | - | Estudiantes | 5:3 (1:1, 2:1) pso | ||
| 1st(1st leg): 08/08/2018 01:45 | 2nd (2nd leg): 29/08/2018 01:45 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Boca Juniors | - | Libertad | 2:0 (2:0) | ||
| 2nd (2nd leg) | Libertad | - | Boca Juniors | 2:4 (2:2) | ||
| 1st(1st leg): 08/08/2018 23:30 | 2nd (2nd leg): 30/08/2018 23:30 | Winner: Boca Juniors | ||||
| 1st(1st leg) | Colo-Colo | - | Corinthians SP | 1:0 (1:0) | ||
| 2nd (2nd leg) | Corinthians SP | - | Colo-Colo | 2:1 (1:1) | ||
| 1st(1st leg): 09/08/2018 01:45 | 2nd (2nd leg): 30/08/2018 01:45 | Winner: Colo-Colo | ||||
| 1st(1st leg) | Flamengo RJ | - | Cruzeiro | 0:2 (0:1) | ||
| 2nd (2nd leg) | Cruzeiro | - | Flamengo RJ | 0:1 (0:0) | ||
| 1st(1st leg): 09/08/2018 01:45 | 2nd (2nd leg): 30/08/2018 01:45 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Racing Club | - | River Plate | 0:0 (0:0) | ||
| 2nd (2nd leg) | River Plate | - | Racing Club | 3:0 (2:0) | ||
| 1st(1st leg): 09/08/2018 23:30 | 2nd (2nd leg): 29/08/2018 23:30 | Winner: River Plate | ||||
| 1st(1st leg) | Atlético Tucumán | - | Atlético Nacional | 2:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Atlético Tucumán | 1:0 (1:0) | ||
| 1st(1st leg): 10/08/2018 01:45 | 2nd (2nd leg): 29/08/2018 01:45 | Winner: Atlético Tucumán | ||||
| 1st(1st leg) | Cerro Porteño | - | Palmeiras | 0:2 (0:0) | ||
| 2nd (2nd leg) | Palmeiras | - | Cerro Porteño | 0:1 (0:0) | ||
| 1st(1st leg): 10/08/2018 01:45 | 2nd (2nd leg): 31/08/2018 01:45 | Winner: Palmeiras | ||||
| 1st(1st leg) | Independiente | - | Santos FC | 3:0 (0:0) dec. | ||
| 2nd (2nd leg) | Santos FC | - | Independiente | 0:0 (0:0) | ||
| 1st(1st leg): 22/08/2018 01:45 | 2nd (2nd leg): 28/08/2018 23:30 | Winner: Independiente | ||||
