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| 1st(1st leg) | Santiago Wanderers | - | Santa Fe | 1:2 (0:2) | ||
| 2nd (2nd leg) | Santa Fe | - | Santiago Wanderers | 3:0 (1:0) | ||
| 1st(1st leg): 14/02/2018 00:30 | 2nd (2nd leg): 21/02/2018 00:30 | Winner: Santa Fe | ||||
| 1st(1st leg) | Banfield | - | Nacional | 2:2 (0:0) | ||
| 2nd (2nd leg) | Nacional | - | Banfield | 1:0 (0:0) | ||
| 1st(1st leg): 14/02/2018 22:00 | 2nd (2nd leg): 22/02/2018 00:45 | Winner: Nacional | ||||
| 1st(1st leg) | Vasco da Gama - RJ | - | Jorge Wilstermann | 4:0 (2:0) | ||
| 2nd (2nd leg) | Jorge Wilstermann | - | Vasco da Gama - RJ | 2:3 (3:0, 4:0) pso | ||
| 1st(1st leg): 14/02/2018 23:45 | 2nd (2nd leg): 22/02/2018 00:45 | Winner: Vasco da Gama - RJ | ||||
| 1st(1st leg) | Atlético Junior | - | Guaraní | 1:0 (0:0) | ||
| 2nd (2nd leg) | Guaraní | - | Atlético Junior | 0:0 (0:0) | ||
| 1st(1st leg): 15/02/2018 22:15 | 2nd (2nd leg): 23/02/2018 00:30 | Winner: Atlético Junior | ||||
