 |
 |
|
|
| 1st(1st leg) | São Paulo FC | - | Atlético Mineiro | 1:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | São Paulo FC | 2:1 (2:1) | ||
| 1st(1st leg): 12/05/2016 01:45 | 2nd (2nd leg): 19/05/2016 01:45 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Nacional | - | Boca Juniors | 1:1 (0:0) | ||
| 2nd (2nd leg) | Boca Juniors | - | Nacional | 4:3 (0:1, 1:1) pso | ||
| 1st(1st leg): 12/05/2016 23:30 | 2nd (2nd leg): 20/05/2016 00:15 | Winner: Boca Juniors | ||||
| 1st(1st leg) | Rosario Central | - | Atlético Nacional | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Rosario Central | 3:1 (1:1) | ||
| 1st(1st leg): 13/05/2016 01:45 | 2nd (2nd leg): 20/05/2016 02:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Independiente del Valle | - | Pumas UNAM | 2:1 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Independiente del Valle | 3:5 (2:0, 2:1) pso | ||
| 1st(1st leg): 18/05/2016 01:45 | 2nd (2nd leg): 25/05/2016 01:45 | Winner: Independiente del Valle | ||||
