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| 1st(1st leg) | Huracán | - | Caracas FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Caracas FC | - | Huracán | 2:1 (1:0) | ||
| 1st(1st leg): 02/02/2016 22:30 | 2nd (2nd leg): 10/02/2016 00:45 | Winner: Huracán | ||||
| 1st(1st leg) | River Plate | - | Universidad de Chile | 2:0 (0:0) | ||
| 2nd (2nd leg) | Universidad de Chile | - | River Plate | 0:0 (0:0) | ||
| 1st(1st leg): 03/02/2016 00:45 | 2nd (2nd leg): 09/02/2016 22:30 | Winner: River Plate | ||||
| 1st(1st leg) | Universidad Cesar Vallejo | - | São Paulo FC | 1:1 (1:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Universidad Cesar Vallejo | 1:0 (0:0) | ||
| 1st(1st leg): 03/02/2016 23:45 | 2nd (2nd leg): 10/02/2016 23:45 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Puebla FC | - | Racing Club | 2:2 (1:1) | ||
| 2nd (2nd leg) | Racing Club | - | Puebla FC | 1:0 (0:0) | ||
| 1st(1st leg): 04/02/2016 02:15 | 2nd (2nd leg): 11/02/2016 00:45 | Winner: Racing Club | ||||
| 1st(1st leg) | Independiente del Valle | - | Guaraní | 1:0 (1:0) | ||
| 2nd (2nd leg) | Guaraní | - | Independiente del Valle | 2:1 (0:0) | ||
| 1st(1st leg): 04/02/2016 22:30 | 2nd (2nd leg): 11/02/2016 22:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Oriente Petrolero | - | Santa Fe | 1:3 (0:2) | ||
| 2nd (2nd leg) | Santa Fe | - | Oriente Petrolero | 3:0 (2:0) | ||
| 1st(1st leg): 05/02/2016 00:45 | 2nd (2nd leg): 12/02/2016 01:00 | Winner: Santa Fe | ||||
