 |
 |
| 1st(1st leg) | Waterhouse FC | - | Pacific FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Pacific FC | - | Waterhouse FC | 6:0 (2:0) | ||
| 1st(1st leg): 27/07/2022 01:00 | 2nd (2nd leg): 03/08/2022 03:00 | Winner: Pacific FC | ||||
| 1st(1st leg) | CD Águila | - | LD Alajuelense | 1:1 (0:0) | ||
| 2nd (2nd leg) | LD Alajuelense | - | CD Águila | 3:0 (1:0) | ||
| 1st(1st leg): 27/07/2022 03:00 | 2nd (2nd leg): 03/08/2022 01:00 | Winner: LD Alajuelense | ||||
| 1st(1st leg) | Deportivo Malacateco | - | Sporting San Miguelito | 1:1 (0:0) | ||
| 2nd (2nd leg) | Sporting San Miguelito | - | Deportivo Malacateco | 3:0 (2:0) | ||
| 1st(1st leg): 28/07/2022 01:00 | 2nd (2nd leg): 04/08/2022 01:00 | Winner: Sporting San Miguelito | ||||
| 1st(1st leg) | Hankook Verdes | - | Platense Zacatecoluca | 0:0 (0:0) | ||
| 2nd (2nd leg) | Platense Zacatecoluca | - | Hankook Verdes | 2:2 (0:2) | ||
| 1st(1st leg): 28/07/2022 03:00 | 2nd (2nd leg): 04/08/2022 03:00 | Winner: Hankook Verdes | ||||
| 1st(1st leg) | Real Vega | - | CSD Municipal | 0:4 (0:2) | ||
| 2nd (2nd leg) | CSD Municipal | - | Real Vega | 5:0 (3:0) | ||
| 1st(1st leg): 29/07/2022 01:00 | 2nd (2nd leg): 05/08/2022 03:00 | Winner: CSD Municipal | ||||
| 1st(1st leg) | Real Estelí FC | - | Real España | 0:0 (0:0) | ||
| 2nd (2nd leg) | Real España | - | Real Estelí FC | 3:1 (1:1) | ||
| 1st(1st leg): 29/07/2022 03:00 | 2nd (2nd leg): 05/08/2022 01:00 | Winner: Real España | ||||
