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| 1st(1st leg) | Alianza | - | LD Alajuelense | 0:1 (0:1) | ||
| 2nd (2nd leg) | LD Alajuelense | - | Alianza | 2:0 (1:0) | ||
| 1st(1st leg): 08/09/2022 03:00 | 2nd (2nd leg): 14/09/2022 03:00 | Winner: LD Alajuelense | ||||
| 1st(1st leg) | Motagua | - | Tauro FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | Tauro FC | - | Motagua | 4:5 (0:0, 0:0) pso | ||
| 1st(1st leg): 08/09/2022 23:00 | 2nd (2nd leg): 15/09/2022 03:00 | Winner: Motagua | ||||
| 1st(1st leg) | Real España | - | CS Herediano | 3:1 (0:0) | ||
| 2nd (2nd leg) | CS Herediano | - | Real España | 1:1 (0:1) | ||
| 1st(1st leg): 09/09/2022 01:00 | 2nd (2nd leg): 16/09/2022 01:00 | Winner: Real España | ||||
| 1st(1st leg) | Diriangén FC | - | Olimpia | 0:4 (0:3) | ||
| 2nd (2nd leg) | Olimpia | - | Diriangén FC | 3:1 (0:1) | ||
| 1st(1st leg): 09/09/2022 03:00 | 2nd (2nd leg): 16/09/2022 03:15 | Winner: Olimpia | ||||
