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| 1st(1st leg) | Sporting San Miguelito | - | Tauro FC | 0:1 (0:0) | ||
| 2nd (2nd leg) | Tauro FC | - | Sporting San Miguelito | 1:1 (0:1) | ||
| 1st(1st leg): 16/08/2022 23:00 | 2nd (2nd leg): 23/08/2022 23:00 | Winner: Tauro FC | ||||
| 1st(1st leg) | Comunicaciones | - | Diriangén FC | 0:1 (0:1) | ||
| 2nd (2nd leg) | Diriangén FC | - | Comunicaciones | 1:1 (1:0) | ||
| 1st(1st leg): 17/08/2022 01:00 | 2nd (2nd leg): 24/08/2022 03:30 | Winner: Diriangén FC | ||||
| 1st(1st leg) | Pacific FC | - | CS Herediano | 0:1 (0:0) | ||
| 2nd (2nd leg) | CS Herediano | - | Pacific FC | 6:5 (0:0, 0:1) pso | ||
| 1st(1st leg): 17/08/2022 03:00 | 2nd (2nd leg): 24/08/2022 01:15 | Winner: CS Herediano | ||||
| 1st(1st leg) | Cibao FC | - | Motagua | 0:1 (0:0) | ||
| 2nd (2nd leg) | Motagua | - | Cibao FC | 2:0 (0:0) | ||
| 1st(1st leg): 18/08/2022 01:00 | 2nd (2nd leg): 25/08/2022 01:00 | Winner: Motagua | ||||
| 1st(1st leg) | Hankook Verdes | - | Alianza | 0:2 (0:0) | ||
| 2nd (2nd leg) | Alianza | - | Hankook Verdes | 5:1 (2:0) | ||
| 1st(1st leg): 18/08/2022 03:00 | 2nd (2nd leg): 25/08/2022 03:15 | Winner: Alianza | ||||
| 1st(1st leg) | Real España | - | CS Cartaginés | 2:0 (1:0) | ||
| 2nd (2nd leg) | CS Cartaginés | - | Real España | 0:2 (0:2) | ||
| 1st(1st leg): 18/08/2022 23:00 | 2nd (2nd leg): 25/08/2022 23:00 | Winner: Real España | ||||
| 1st(1st leg) | LD Alajuelense | - | Alianza | 5:0 (4:0) | ||
| 2nd (2nd leg) | Alianza | - | LD Alajuelense | 1:1 (0:1) | ||
| 1st(1st leg): 19/08/2022 01:00 | 2nd (2nd leg): 26/08/2022 01:15 | Winner: LD Alajuelense | ||||
| 1st(1st leg) | CSD Municipal | - | Olimpia | 2:2 (0:2) | ||
| 2nd (2nd leg) | Olimpia | - | CSD Municipal | 1:0 (0:0) | ||
| 1st(1st leg): 19/08/2022 03:00 | 2nd (2nd leg): 26/08/2022 03:30 | Winner: Olimpia | ||||
