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| 1st(1st leg) | Comunicaciones | - | CF Monterrey | 1:4 (1:1) | ||
| 2nd (2nd leg) | CF Monterrey | - | Comunicaciones | 3:0 (2:0) | ||
| 1st(1st leg): 07/02/2024 01:00 | 2nd (2nd leg): 16/02/2024 03:15 | Winner: CF Monterrey | ||||
| 1st(1st leg) | Real Estelí FC | - | CF América | 2:1 (1:0) | ||
| 2nd (2nd leg) | CF América | - | Real Estelí FC | 2:0 (1:0) | ||
| 1st(1st leg): 07/02/2024 03:00 | 2nd (2nd leg): 15/02/2024 03:15 | Winner: CF América | ||||
| 1st(1st leg) | CS Herediano | - | Deportivo Toluca | 1:2 (0:1) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | CS Herediano | 2:3 (2:0) | ||
| 1st(1st leg): 07/02/2024 23:00 | 2nd (2nd leg): 16/02/2024 01:00 | Winner: CS Herediano | ||||
| 1st(1st leg) | Forge FC | - | Deportivo Guadalajara | 1:3 (1:2) | ||
| 2nd (2nd leg) | Deportivo Guadalajara | - | Forge FC | 2:1 (1:0) | ||
| 1st(1st leg): 08/02/2024 01:00 | 2nd (2nd leg): 14/02/2024 03:00 | Winner: Deportivo Guadalajara | ||||
| 1st(1st leg) | Vancouver Whitecaps | - | UANL Tigres | 1:1 (1:0) | ||
| 2nd (2nd leg) | UANL Tigres | - | Vancouver Whitecaps | 3:0 (0:0) | ||
| 1st(1st leg): 08/02/2024 03:00 | 2nd (2nd leg): 15/02/2024 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | St. Louis City SC | - | Houston Dynamo | 2:1 (0:0) | ||
| 2nd (2nd leg) | Houston Dynamo | - | St. Louis City SC | 1:0 (0:0) | ||
| 1st(1st leg): 21/02/2024 01:00 | 2nd (2nd leg): 28/02/2024 03:30 | Winner: Houston Dynamo | ||||
| 1st(1st leg) | Deportivo Saprissa | - | Philadelphia Union | 2:3 (1:0) | ||
| 2nd (2nd leg) | Philadelphia Union | - | Deportivo Saprissa | 3:3 (2:2, 2:3) aet | ||
| 1st(1st leg): 21/02/2024 03:00 | 2nd (2nd leg): 28/02/2024 01:15 | Winner: Philadelphia Union | ||||
| 1st(1st leg) | Independiente de La Chorrera | - | New England Revolution | 0:1 (0:0) | ||
| 2nd (2nd leg) | New England Revolution | - | Independiente de La Chorrera | 3:0 (1:0) | ||
| 1st(1st leg): 22/02/2024 01:00 | 2nd (2nd leg): 01/03/2024 01:15 | Winner: New England Revolution | ||||
| 1st(1st leg) | Cavalry FC | - | Orlando City | 0:3 (0:2) | ||
| 2nd (2nd leg) | Orlando City | - | Cavalry FC | 3:1 (0:0) | ||
| 1st(1st leg): 22/02/2024 03:00 | 2nd (2nd leg): 27/02/2024 23:00 | Winner: Orlando City | ||||
| 1st(1st leg) | Moca FC | - | Nashville SC | 0:3 (0:2) | ||
| 2nd (2nd leg) | Nashville SC | - | Moca FC | 4:0 (3:0) | ||
| 1st(1st leg): 23/02/2024 00:00 | 2nd (2nd leg): 29/02/2024 02:15 | Winner: Nashville SC | ||||
| 1st(1st leg) | Cavalier FC | - | FC Cincinnati | 0:2 (0:1) | ||
| 2nd (2nd leg) | FC Cincinnati | - | Cavalier FC | 4:0 (2:0) | ||
| 1st(1st leg): 23/02/2024 02:00 | 2nd (2nd leg): 29/02/2024 00:00 | Winner: FC Cincinnati | ||||
