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| 1st(1st leg) | Portmore United | - | Cruz Azul | 1:2 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Portmore United | 4:0 (1:0) | ||
| 1st(1st leg): 19/02/2020 01:00 | 2nd (2nd leg): 26/02/2020 03:15 | Winner: Cruz Azul | ||||
| 1st(1st leg) | Motagua | - | Atlanta United FC | 1:1 (1:1) | ||
| 2nd (2nd leg) | Atlanta United FC | - | Motagua | 3:0 (1:0) | ||
| 1st(1st leg): 19/02/2020 03:00 | 2nd (2nd leg): 26/02/2020 01:00 | Winner: Atlanta United FC | ||||
| 1st(1st leg) | Club León | - | Los Angeles FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Los Angeles FC | - | Club León | 3:0 (1:0) | ||
| 1st(1st leg): 19/02/2020 03:00 | 2nd (2nd leg): 28/02/2020 03:00 | Winner: Los Angeles FC | ||||
| 1st(1st leg) | Alianza | - | UANL Tigres | 2:1 (0:1) | ||
| 2nd (2nd leg) | UANL Tigres | - | Alianza | 4:2 (3:2) | ||
| 1st(1st leg): 20/02/2020 01:00 | 2nd (2nd leg): 27/02/2020 01:00 | Winner: UANL Tigres | ||||
| 1st(1st leg) | Deportivo Saprissa | - | Impact de Montréal | 2:2 (0:2) | ||
| 2nd (2nd leg) | Impact de Montréal | - | Deportivo Saprissa | 0:0 (0:0) | ||
| 1st(1st leg): 20/02/2020 01:00 | 2nd (2nd leg): 27/02/2020 01:00 | Winner: Impact de Montréal | ||||
| 1st(1st leg) | Comunicaciones | - | CF América | 1:1 (0:0) | ||
| 2nd (2nd leg) | CF América | - | Comunicaciones | 5:3 (0:0, 1:1) pso | ||
| 1st(1st leg): 20/02/2020 03:00 | 2nd (2nd leg): 27/02/2020 03:15 | Winner: CF América | ||||
| 1st(1st leg) | AD San Carlos | - | New York City FC | 3:5 (1:2) | ||
| 2nd (2nd leg) | New York City FC | - | AD San Carlos | 1:0 (1:0) | ||
| 1st(1st leg): 21/02/2020 01:00 | 2nd (2nd leg): 26/02/2020 23:00 | Winner: New York City FC | ||||
| 1st(1st leg) | Olimpia | - | Seattle Sounders | 2:2 (0:1) | ||
| 2nd (2nd leg) | Seattle Sounders | - | Olimpia | 2:4 (1:1, 2:2) pso | ||
| 1st(1st leg): 21/02/2020 03:00 | 2nd (2nd leg): 28/02/2020 03:00 | Winner: Olimpia | ||||
