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| 1st(1st leg) | Columbus Crew | - | Deportivo Toluca | 2:2 (0:2) | ||
| 2nd (2nd leg) | Deportivo Toluca | - | Columbus Crew | 3:2 (0:1) | ||
| 1st(1st leg): 10/03/2010 01:00 | 2nd (2nd leg): 18/03/2010 00:00 | Winner: Deportivo Toluca | ||||
| 1st(1st leg) | Marathón | - | Pumas UNAM | 2:0 (1:0) | ||
| 2nd (2nd leg) | Pumas UNAM | - | Marathón | 6:1 (3:0) | ||
| 1st(1st leg): 11/03/2010 01:00 | 2nd (2nd leg): 19/03/2010 02:00 | Winner: Pumas UNAM | ||||
| 1st(1st leg) | CSD Comunicaciones | - | CF Pachuca | 1:1 (0:1) | ||
| 2nd (2nd leg) | CF Pachuca | - | CSD Comunicaciones | 2:1 (0:0) | ||
| 1st(1st leg): 11/03/2010 03:00 | 2nd (2nd leg): 17/03/2010 02:00 | Winner: CF Pachuca | ||||
| 1st(1st leg) | Árabe Unido | - | Cruz Azul | 0:1 (0:0) | ||
| 2nd (2nd leg) | Cruz Azul | - | Árabe Unido | 3:0 (0:0) | ||
| 1st(1st leg): 12/03/2010 01:00 | 2nd (2nd leg): 18/03/2010 02:00 | Winner: Cruz Azul | ||||
