 |
 |
| 1st(1st leg) | América de Cali | - | Santa Fe | 1:2 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | América de Cali | 3:2 (1:1) | ||
| 1st(1st leg): 06/10/2021 01:45 | 2nd (2nd leg): 21/10/2021 02:00 | Winner: Santa Fe | ||||
|
|
| 1st(1st leg) | América de Cali | - | Santa Fe | 1:2 (1:0) | ||
| 2nd (2nd leg) | Santa Fe | - | América de Cali | 3:2 (1:1) | ||
| 1st(1st leg): 06/10/2021 01:45 | 2nd (2nd leg): 21/10/2021 02:00 | Winner: Santa Fe | ||||
