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| 1st(1st leg) | Once Caldas | - | Deportes Tolima | 1:0 (1:0) | ||
| 2nd (2nd leg) | Deportes Tolima | - | Once Caldas | 3:1 (1:1) | ||
| 1st(1st leg): 28/11/2015 22:30 | 2nd (2nd leg): 05/12/2015 22:30 | Winner: Deportes Tolima | ||||
| 1st(1st leg) | Santa Fe | - | Atlético Junior | 2:1 (1:1) | ||
| 2nd (2nd leg) | Atlético Junior | - | Santa Fe | 3:1 (2:1) | ||
| 1st(1st leg): 29/11/2015 00:45 | 2nd (2nd leg): 06/12/2015 22:00 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Deportivo Cali | - | Atlético Nacional | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Deportivo Cali | 3:1 (2:1) | ||
| 1st(1st leg): 29/11/2015 22:00 | 2nd (2nd leg): 06/12/2015 01:00 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Alianza Petrolera | - | Independiente Medellín | 0:2 (0:2) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Alianza Petrolera | 4:0 (1:0) | ||
| 1st(1st leg): 30/11/2015 00:30 | 2nd (2nd leg): 07/12/2015 00:30 | Winner: Independiente Medellín | ||||
