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| 1st(1st leg) | Unión Magdalena | - | Tigres FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Tigres FC | - | Unión Magdalena | 4:2 (1:0, 1:0) pso | ||
| 1st(1st leg): 05/04/2023 21:30 | 2nd (2nd leg): 02/05/2023 21:00 | Winner: Tigres FC | ||||
| 1st(1st leg) | Deportivo Cali | - | Jaguares de Córdoba | 1:0 (1:0) | ||
| 2nd (2nd leg) | Jaguares de Córdoba | - | Deportivo Cali | 3:5 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 06/04/2023 01:00 | 2nd (2nd leg): 04/05/2023 21:45 | Winner: Deportivo Cali | ||||
| 1st(1st leg) | Orsomarso SC | - | Alianza Petrolera | 1:1 (0:0) | ||
| 2nd (2nd leg) | Alianza Petrolera | - | Orsomarso SC | 3:1 (0:0) | ||
| 1st(1st leg): 06/04/2023 20:50 | 2nd (2nd leg): 03/05/2023 01:40 | Winner: Alianza Petrolera | ||||
| 1st(1st leg) | Real Cartagena | - | Cúcuta Deportivo | 0:1 (0:1) | ||
| 2nd (2nd leg) | Cúcuta Deportivo | - | Real Cartagena | 0:0 (0:0) | ||
| 1st(1st leg): 13/04/2023 00:00 | 2nd (2nd leg): 03/05/2023 21:45 | Winner: Cúcuta Deportivo | ||||
