 |
 |
|
| 1st(1st leg) | Orsomarso SC | - | Atlético Huila | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Huila | - | Orsomarso SC | 0:0 (0:0) | ||
| 1st(1st leg): 14/02/2023 21:00 | 2nd (2nd leg): 21/02/2023 23:00 | Winner: Orsomarso SC | ||||
| 1st(1st leg) | Valledupar FC | - | Jaguares de Córdoba | 0:2 (0:0) | ||
| 2nd (2nd leg) | Jaguares de Córdoba | - | Valledupar FC | 1:0 (1:0) | ||
| 1st(1st leg): 14/02/2023 23:00 | 2nd (2nd leg): 22/02/2023 22:30 | Winner: Jaguares de Córdoba | ||||
| 1st(1st leg) | Atlético FC | - | Envigado FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Envigado FC | - | Atlético FC | 4:2 (1:0, 2:0) pso | ||
| 1st(1st leg): 15/02/2023 20:00 | 2nd (2nd leg): 22/02/2023 22:30 | Winner: Envigado FC | ||||
| 1st(1st leg) | Boyacá Chicó | - | Real Cartagena | 1:1 (1:1) | ||
| 2nd (2nd leg) | Real Cartagena | - | Boyacá Chicó | 8:7 (0:0, 0:0) pso | ||
| 1st(1st leg): 15/02/2023 22:15 | 2nd (2nd leg): 23/02/2023 22:30 | Winner: Real Cartagena | ||||
| 1st(1st leg) | Alianza Petrolera | - | Real Santander | 4:1 (2:0) | ||
| 2nd (2nd leg) | Real Santander | - | Alianza Petrolera | 1:0 (0:0) | ||
| 1st(1st leg): 15/02/2023 23:00 | 2nd (2nd leg): 23/02/2023 20:00 | Winner: Alianza Petrolera | ||||
| 1st(1st leg) | Cúcuta Deportivo | - | Once Caldas | 3:1 (2:1) | ||
| 2nd (2nd leg) | Once Caldas | - | Cúcuta Deportivo | 1:0 (0:0) | ||
| 1st(1st leg): 16/02/2023 20:30 | 2nd (2nd leg): 23/02/2023 01:00 | Winner: Cúcuta Deportivo | ||||
| 1st(1st leg) | Boca Juniors de Cali | - | Unión Magdalena | 0:1 (0:0) | ||
| 2nd (2nd leg) | Unión Magdalena | - | Boca Juniors de Cali | 3:0 (1:0) | ||
| 1st(1st leg): 16/02/2023 21:00 | 2nd (2nd leg): 22/02/2023 21:00 | Winner: Unión Magdalena | ||||
| 1st(1st leg) | Barranquilla FC | - | Deportivo Cali | 3:3 (1:2) | ||
| 2nd (2nd leg) | Deportivo Cali | - | Barranquilla FC | 6:0 (3:0) | ||
| 1st(1st leg): 16/02/2023 22:30 | 2nd (2nd leg): 24/02/2023 01:00 | Winner: Deportivo Cali | ||||
