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| 1st(1st leg) | Deportivo Pereira | - | Tigres FC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Tigres FC | - | Deportivo Pereira | 1:1 (0:0) | ||
| 1st(1st leg): 21/10/2020 21:00 | 2nd (2nd leg): 29/10/2020 19:00 | Winner: Deportivo Pereira | ||||
| 1st(1st leg) | Jaguares de Córdoba | - | Deportes Quindío | 0:1 (0:0) | ||
| 2nd (2nd leg) | Deportes Quindío | - | Jaguares de Córdoba | 4:3 (0:0, 0:1) pso | ||
| 1st(1st leg): 21/10/2020 21:00 | 2nd (2nd leg): 29/10/2020 00:00 | Winner: Deportes Quindío | ||||
| 1st(1st leg) | La Equidad | - | Cúcuta Deportivo | 1:2 (0:1) | ||
| 2nd (2nd leg) | Cúcuta Deportivo | - | La Equidad | 3:2 (2:0) | ||
| 1st(1st leg): 22/10/2020 00:00 | 2nd (2nd leg): 29/10/2020 22:45 | Winner: Cúcuta Deportivo | ||||
| 1st(1st leg) | Boyacá Chicó | - | Real San Andrés | 1:1 (0:1) | ||
| 2nd (2nd leg) | Real San Andrés | - | Boyacá Chicó | 2:1 (1:1) | ||
| 1st(1st leg): 22/10/2020 02:00 | 2nd (2nd leg): 29/10/2020 20:00 | Winner: Real San Andrés | ||||
| 1st(1st leg) | Envigado FC | - | Once Caldas | 3:0 (1:0) | ||
| 2nd (2nd leg) | Once Caldas | - | Envigado FC | 2:0 (2:0) | ||
| 1st(1st leg): 22/10/2020 02:00 | 2nd (2nd leg): 29/10/2020 00:40 | Winner: Envigado FC | ||||
| 1st(1st leg) | Águilas Doradas | - | Leones FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Leones FC | - | Águilas Doradas | 1:2 (1:0) | ||
| 1st(1st leg): 23/10/2020 00:00 | 2nd (2nd leg): 29/10/2020 20:00 | Winner: Águilas Doradas | ||||
| 1st(1st leg) | Atlético Bucaramanga | - | Alianza Petrolera | 2:0 (1:0) | ||
| 2nd (2nd leg) | Alianza Petrolera | - | Atlético Bucaramanga | 4:0 (2:0) | ||
| 1st(1st leg): 23/10/2020 00:00 | 2nd (2nd leg): 30/10/2020 01:10 | Winner: Alianza Petrolera | ||||
| 1st(1st leg) | Patriotas FC | - | Santa Fe | 1:3 (0:2) | ||
| 2nd (2nd leg) | Santa Fe | - | Patriotas FC | 1:2 (1:0) | ||
| 1st(1st leg): 23/10/2020 02:00 | 2nd (2nd leg): 29/10/2020 20:30 | Winner: Santa Fe | ||||
