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| 1st(1st leg) | Huachipato | - | CD Magallanes | 0:1 (0:1) | ||
| 2nd (2nd leg) | CD Magallanes | - | Huachipato | 1:1 (0:0) | ||
| 1st(1st leg): 13/10/2022 00:00 | 2nd (2nd leg): 16/10/2022 16:00 | Winner: CD Magallanes | ||||
| 1st(1st leg) | Universidad de Chile | - | Unión Española | 0:0 (0:0) | ||
| 2nd (2nd leg) | Unión Española | - | Universidad de Chile | 1:0 (0:0) | ||
| 1st(1st leg): 26/10/2022 22:00 | 2nd (2nd leg): 02/11/2022 22:00 | Winner: Unión Española | ||||
