1st(1st leg) FK Astana - APOEL Nikosia 1:0 (1:0)
2nd (2nd leg) APOEL Nikosia - FK Astana 1:1 (0:0)
1st(1st leg): 18/08/2015 17:00 2nd (2nd leg): 26/08/2015 19:45 Winner: FK Astana
1st(1st leg) BATE Borisov - Partizan 1:0 (0:0)
2nd (2nd leg) Partizan - BATE Borisov 2:1 (0:1)
1st(1st leg): 18/08/2015 19:45 2nd (2nd leg): 26/08/2015 19:45 Winner: BATE Borisov
1st(1st leg) Lazio Roma - Bayer Leverkusen 1:0 (0:0)
2nd (2nd leg) Bayer Leverkusen - Lazio Roma 3:0 (1:0)
1st(1st leg): 18/08/2015 19:45 2nd (2nd leg): 26/08/2015 19:45 Winner: Bayer Leverkusen
1st(1st leg) Manchester United - Club Brugge KV 3:1 (2:1)
2nd (2nd leg) Club Brugge KV - Manchester United 0:4 (0:1)
1st(1st leg): 18/08/2015 19:45 2nd (2nd leg): 26/08/2015 19:45 Winner: Manchester United
1st(1st leg) Sporting CP - CSKA Moskva 2:1 (1:1)
2nd (2nd leg) CSKA Moskva - Sporting CP 3:1 (0:1)
1st(1st leg): 18/08/2015 19:45 2nd (2nd leg): 26/08/2015 19:45 Winner: CSKA Moskva
1st(1st leg) KF Skënderbeu - Dinamo Zagreb 1:2 (1:0)
2nd (2nd leg) Dinamo Zagreb - KF Skënderbeu 4:1 (2:1)
1st(1st leg): 19/08/2015 19:45 2nd (2nd leg): 25/08/2015 19:45 Winner: Dinamo Zagreb
1st(1st leg) Celtic FC - Malmö FF 3:2 (2:0)
2nd (2nd leg) Malmö FF - Celtic FC 2:0 (1:0)
1st(1st leg): 19/08/2015 19:45 2nd (2nd leg): 25/08/2015 19:45 Winner: Malmö FF
1st(1st leg) FC Basel 1893 - Maccabi Tel Aviv 2:2 (1:1)
2nd (2nd leg) Maccabi Tel Aviv - FC Basel 1893 1:1 (1:1)
1st(1st leg): 19/08/2015 19:45 2nd (2nd leg): 25/08/2015 19:45 Winner: Maccabi Tel Aviv
1st(1st leg) Rapid Wien - Shakhtar Donetsk 0:1 (0:1)
2nd (2nd leg) Shakhtar Donetsk - Rapid Wien 2:2 (2:2)
1st(1st leg): 19/08/2015 19:45 2nd (2nd leg): 25/08/2015 19:45 Winner: Shakhtar Donetsk
1st(1st leg) Valencia CF - AS Monaco 3:1 (1:0)
2nd (2nd leg) AS Monaco - Valencia CF 2:1 (1:1)
1st(1st leg): 19/08/2015 19:45 2nd (2nd leg): 25/08/2015 19:45 Winner: Valencia CF