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| 1st(1st leg) | Manchester United | - | Paris Saint-Germain | 0:2 (0:0) | ||
| 2nd (2nd leg) | Paris Saint-Germain | - | Manchester United | 1:3 (1:2) | ||
| 1st(1st leg): 12/02/2019 20:00 | 2nd (2nd leg): 06/03/2019 20:00 | Winner: Manchester United | ||||
| 1st(1st leg) | AS Roma | - | FC Porto | 2:1 (0:0) | ||
| 2nd (2nd leg) | FC Porto | - | AS Roma | 3:1 (1:1, 2:1) aet | ||
| 1st(1st leg): 12/02/2019 20:00 | 2nd (2nd leg): 06/03/2019 20:00 | Winner: FC Porto | ||||
| 1st(1st leg) | Tottenham Hotspur | - | Borussia Dortmund | 3:0 (0:0) | ||
| 2nd (2nd leg) | Borussia Dortmund | - | Tottenham Hotspur | 0:1 (0:0) | ||
| 1st(1st leg): 13/02/2019 20:00 | 2nd (2nd leg): 05/03/2019 20:00 | Winner: Tottenham Hotspur | ||||
| 1st(1st leg) | AFC Ajax | - | Real Madrid | 1:2 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | AFC Ajax | 1:4 (0:2) | ||
| 1st(1st leg): 13/02/2019 20:00 | 2nd (2nd leg): 05/03/2019 20:00 | Winner: AFC Ajax | ||||
| 1st(1st leg) | Olympique Lyonnais | - | FC Barcelona | 0:0 (0:0) | ||
| 2nd (2nd leg) | FC Barcelona | - | Olympique Lyonnais | 5:1 (2:0) | ||
| 1st(1st leg): 19/02/2019 20:00 | 2nd (2nd leg): 13/03/2019 20:00 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Liverpool FC | - | Bayern München | 0:0 (0:0) | ||
| 2nd (2nd leg) | Bayern München | - | Liverpool FC | 1:3 (1:1) | ||
| 1st(1st leg): 19/02/2019 20:00 | 2nd (2nd leg): 13/03/2019 20:00 | Winner: Liverpool FC | ||||
| 1st(1st leg) | FC Schalke 04 | - | Manchester City | 2:3 (2:1) | ||
| 2nd (2nd leg) | Manchester City | - | FC Schalke 04 | 7:0 (3:0) | ||
| 1st(1st leg): 20/02/2019 20:00 | 2nd (2nd leg): 12/03/2019 20:00 | Winner: Manchester City | ||||
| 1st(1st leg) | Atlético Madrid | - | Juventus | 2:0 (0:0) | ||
| 2nd (2nd leg) | Juventus | - | Atlético Madrid | 3:0 (1:0) | ||
| 1st(1st leg): 20/02/2019 20:00 | 2nd (2nd leg): 12/03/2019 20:00 | Winner: Juventus | ||||
