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| 1st(1st leg) | AC Milan | - | Tottenham Hotspur | 0:1 (0:0) | ||
| 2nd (2nd leg) | Tottenham Hotspur | - | AC Milan | 0:0 (0:0) | ||
| 1st(1st leg): 15/02/2011 19:45 | 2nd (2nd leg): 09/03/2011 19:45 | Winner: Tottenham Hotspur | ||||
| 1st(1st leg) | Valencia CF | - | FC Schalke 04 | 1:1 (1:0) | ||
| 2nd (2nd leg) | FC Schalke 04 | - | Valencia CF | 3:1 (1:1) | ||
| 1st(1st leg): 15/02/2011 19:45 | 2nd (2nd leg): 09/03/2011 19:45 | Winner: FC Schalke 04 | ||||
| 1st(1st leg) | AS Roma | - | Shakhtar Donetsk | 2:3 (1:3) | ||
| 2nd (2nd leg) | Shakhtar Donetsk | - | AS Roma | 3:0 (1:0) | ||
| 1st(1st leg): 16/02/2011 19:45 | 2nd (2nd leg): 08/03/2011 19:45 | Winner: Shakhtar Donetsk | ||||
| 1st(1st leg) | Arsenal FC | - | FC Barcelona | 2:1 (0:1) | ||
| 2nd (2nd leg) | FC Barcelona | - | Arsenal FC | 3:1 (1:0) | ||
| 1st(1st leg): 16/02/2011 19:45 | 2nd (2nd leg): 08/03/2011 19:45 | Winner: FC Barcelona | ||||
| 1st(1st leg) | Olympique Lyonnais | - | Real Madrid | 1:1 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | Olympique Lyonnais | 3:0 (1:0) | ||
| 1st(1st leg): 22/02/2011 19:45 | 2nd (2nd leg): 16/03/2011 19:45 | Winner: Real Madrid | ||||
| 1st(1st leg) | FC København | - | Chelsea FC | 0:2 (0:1) | ||
| 2nd (2nd leg) | Chelsea FC | - | FC København | 0:0 (0:0) | ||
| 1st(1st leg): 22/02/2011 19:45 | 2nd (2nd leg): 16/03/2011 19:45 | Winner: Chelsea FC | ||||
| 1st(1st leg) | Inter | - | Bayern München | 0:1 (0:0) | ||
| 2nd (2nd leg) | Bayern München | - | Inter | 2:3 (2:1) | ||
| 1st(1st leg): 23/02/2011 19:45 | 2nd (2nd leg): 15/03/2011 19:45 | Winner: Inter | ||||
| 1st(1st leg) | Olympique Marseille | - | Manchester United | 0:0 (0:0) | ||
| 2nd (2nd leg) | Manchester United | - | Olympique Marseille | 2:1 (1:0) | ||
| 1st(1st leg): 23/02/2011 19:45 | 2nd (2nd leg): 15/03/2011 19:45 | Winner: Manchester United | ||||
