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| 1st(1st leg) | Odense BK | - | Lokomotiv Sofia | 2:2 (2:0) | ||
| 2nd (2nd leg) | Lokomotiv Sofia | - | Odense BK | 2:1 (1:1) | ||
| 1st(1st leg): 13/09/1978 | 2nd (2nd leg): 27/09/1978 | Winner: Lokomotiv Sofia | ||||
| 1st(1st leg) | Partizan | - | Dynamo Dresden | 2:0 (1:0) | ||
| 2nd (2nd leg) | Dynamo Dresden | - | Partizan | 5:4 (1:0, 2:0, 2:0) pso | ||
| 1st(1st leg): 13/09/1978 | 2nd (2nd leg): 27/09/1978 16:00 | Winner: Dynamo Dresden | ||||
| 1st(1st leg) | TJ Zbrojovka Brno | - | Újpesti Dózsa SC | 2:2 (0:1) | ||
| 2nd (2nd leg) | Újpesti Dózsa SC | - | TJ Zbrojovka Brno | 0:2 (0:2) | ||
| 1st(1st leg): 13/09/1978 15:00 | 2nd (2nd leg): 27/09/1978 16:45 | Winner: TJ Zbrojovka Brno | ||||
| 1st(1st leg) | FK Vllaznia | - | Austria Wien | 2:0 (1:0) | ||
| 2nd (2nd leg) | Austria Wien | - | FK Vllaznia | 4:1 (2:0) | ||
| 1st(1st leg): 13/09/1978 15:30 | 2nd (2nd leg): 27/09/1978 17:00 | Winner: Austria Wien | ||||
| 1st(1st leg) | Linfield FC | - | Lillestrøm SK | 0:0 (0:0) | ||
| 2nd (2nd leg) | Lillestrøm SK | - | Linfield FC | 1:0 (1:0) | ||
| 1st(1st leg): 13/09/1978 17:30 | 2nd (2nd leg): 27/09/1978 18:00 | Winner: Lillestrøm SK | ||||
| 1st(1st leg) | Haka Valkeakoski | - | Dinamo Kiev | 0:1 (0:0) | ||
| 2nd (2nd leg) | Dinamo Kiev | - | Haka Valkeakoski | 3:1 (2:0) | ||
| 1st(1st leg): 13/09/1978 18:00 | 2nd (2nd leg): 27/09/1978 17:00 | Winner: Dinamo Kiev | ||||
| 1st(1st leg) | Malmö FF | - | AS Monaco | 0:0 (0:0) | ||
| 2nd (2nd leg) | AS Monaco | - | Malmö FF | 0:1 (0:1) | ||
| 1st(1st leg): 13/09/1978 18:00 | 2nd (2nd leg): 27/09/1978 | Winner: Malmö FF | ||||
| 1st(1st leg) | Nottingham Forest | - | Liverpool FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | Liverpool FC | - | Nottingham Forest | 0:0 (0:0) | ||
| 1st(1st leg): 13/09/1978 18:30 | 2nd (2nd leg): 27/09/1978 19:30 | Winner: Nottingham Forest | ||||
| 1st(1st leg) | Omonia Nikosia | - | Bohemian FC | 2:1 (1:1) | ||
| 2nd (2nd leg) | Bohemian FC | - | Omonia Nikosia | 1:0 (1:0) | ||
| 1st(1st leg): 13/09/1978 18:30 | 2nd (2nd leg): 27/09/1978 15:00 | Winner: Bohemian FC | ||||
| 1st(1st leg) | 1. FC Köln | - | ÍA Akranes | 4:1 (3:1) | ||
| 2nd (2nd leg) | ÍA Akranes | - | 1. FC Köln | 1:1 (1:0) | ||
| 1st(1st leg): 13/09/1978 19:00 | 2nd (2nd leg): 27/09/1978 17:00 | Winner: 1. FC Köln | ||||
| 1st(1st leg) | Club Brugge KV | - | Wisła Kraków | 2:1 (2:0) | ||
| 2nd (2nd leg) | Wisła Kraków | - | Club Brugge KV | 3:1 (1:0) | ||
| 1st(1st leg): 13/09/1978 19:00 | 2nd (2nd leg): 27/09/1978 16:00 | Winner: Wisła Kraków | ||||
| 1st(1st leg) | Grasshopper Club Zürich | - | Valletta FC | 8:0 (3:0) | ||
| 2nd (2nd leg) | Valletta FC | - | Grasshopper Club Zürich | 3:5 (0:1) | ||
| 1st(1st leg): 13/09/1978 19:00 | 2nd (2nd leg): 27/09/1978 14:30 | Winner: Grasshopper Club Zürich | ||||
| 1st(1st leg) | Fenerbahçe | - | PSV Eindhoven | 2:1 (2:1) | ||
| 2nd (2nd leg) | PSV Eindhoven | - | Fenerbahçe | 6:1 (2:0) | ||
| 1st(1st leg): 13/09/1978 19:30 | 2nd (2nd leg): 27/09/1978 19:00 | Winner: PSV Eindhoven | ||||
| 1st(1st leg) | Juventus | - | Rangers FC | 1:0 (1:0) | ||
| 2nd (2nd leg) | Rangers FC | - | Juventus | 2:0 (1:0) | ||
| 1st(1st leg): 13/09/1978 19:30 | 2nd (2nd leg): 27/09/1978 18:30 | Winner: Rangers FC | ||||
| 1st(1st leg) | Real Madrid | - | Progrès Niedercorn | 5:0 (3:0) | ||
| 2nd (2nd leg) | Progrès Niedercorn | - | Real Madrid | 0:7 (0:3) | ||
| 1st(1st leg): 13/09/1978 20:00 | 2nd (2nd leg): 27/09/1978 19:00 | Winner: Real Madrid | ||||
| 1st(1st leg) | AEK Athen | - | FC Porto | 6:1 (4:0) | ||
| 2nd (2nd leg) | FC Porto | - | AEK Athen | 4:1 (0:1) | ||
| 1st(1st leg): 13/09/1978 20:00 | 2nd (2nd leg): 27/09/1978 21:45 | Winner: AEK Athen | ||||
