1st(1st leg) KCCA FC - CD 1º de Agosto 1:0
2nd (2nd leg) CD 1º de Agosto - KCCA FC 2:1
1st(1st leg): 10/02/2017 13:00 2nd (2nd leg): 19/02/2017 16:00 Winner: KCCA FC
1st(1st leg) JS Saoura - Enugu Rangers 1:1
2nd (2nd leg) Enugu Rangers - JS Saoura 0:0
1st(1st leg): 10/02/2017 18:00 2nd (2nd leg): 19/02/2017 15:00 Winner: Enugu Rangers
1st(1st leg) CNaPS Sports - Township Rollers FC 2:1
2nd (2nd leg) Township Rollers FC - CNaPS Sports 3:2
1st(1st leg): 11/02/2017 11:30 2nd (2nd leg): 18/02/2017 14:00 Winner: CNaPS Sports
1st(1st leg) Côte d'Or FC - St. George SC 0:2
2nd (2nd leg) St. George SC - Côte d'Or FC 3:0
1st(1st leg): 11/02/2017 12:00 2nd (2nd leg): 19/02/2017 13:00 Winner: St. George SC
1st(1st leg) Tusker FC - AS Port Louis 2000 1:1
2nd (2nd leg) AS Port Louis 2000 - Tusker FC 2:1
1st(1st leg): 11/02/2017 12:00 2nd (2nd leg): 19/02/2017 11:15 Winner: AS Port Louis 2000
1st(1st leg) Zanaco FC - APR FC 0:0
2nd (2nd leg) APR FC - Zanaco FC 0:1
1st(1st leg): 11/02/2017 13:00 2nd (2nd leg): 18/02/2017 13:30 Winner: Zanaco FC
1st(1st leg) Royal Leopards - Vita Club Mokanda 0:1
2nd (2nd leg) Vita Club Mokanda - Royal Leopards 3:1
1st(1st leg): 11/02/2017 13:00 2nd (2nd leg): 19/02/2017 14:30 Winner: Vita Club Mokanda
1st(1st leg) Zimamoto - Ferroviário da Beira 2:1
2nd (2nd leg) Ferroviário da Beira - Zimamoto 3:1
1st(1st leg): 11/02/2017 13:30 2nd (2nd leg): 19/02/2017 13:00 Winner: Ferroviário da Beira
1st(1st leg) Lioli - CAPS United 0:0
2nd (2nd leg) CAPS United - Lioli 2:1
1st(1st leg): 11/02/2017 14:00 2nd (2nd leg): 19/02/2017 13:00 Winner: CAPS United
1st(1st leg) CF Mounana - Vital'O 2:0
2nd (2nd leg) Vital'O - CF Mounana 0:1
1st(1st leg): 11/02/2017 14:30 2nd (2nd leg): 19/02/2017 14:30 Winner: CF Mounana
1st(1st leg) SS Saint-Louisienne - BidVest Wits 2:1
2nd (2nd leg) BidVest Wits - SS Saint-Louisienne 3:1
1st(1st leg): 11/02/2017 15:00 2nd (2nd leg): 18/02/2017 16:00 Winner: BidVest Wits
1st(1st leg) RC Kadiogo - Diables Noirs 3:0
2nd (2nd leg) Diables Noirs - RC Kadiogo 1:0
1st(1st leg): 11/02/2017 16:00 2nd (2nd leg): 19/02/2017 14:30 Winner: RC Kadiogo
1st(1st leg) AS Tanda - AS FAN 3:0
2nd (2nd leg) AS FAN - AS Tanda 3:1
1st(1st leg): 11/02/2017 16:00 2nd (2nd leg): 18/02/2017 15:00 Winner: AS Tanda
1st(1st leg) FC Johansen - FUS de Rabat 1:1
2nd (2nd leg) FUS de Rabat - FC Johansen 3:0
1st(1st leg): 11/02/2017 16:30 2nd (2nd leg): 18/02/2017 19:30 Winner: FUS de Rabat
1st(1st leg) AS Real Bamako - Rivers United 0:0
2nd (2nd leg) Rivers United - AS Real Bamako 4:0
1st(1st leg): 11/02/2017 17:00 2nd (2nd leg): 19/02/2017 15:00 Winner: Rivers United
1st(1st leg) US Gorée - Horoya AC 0:0
2nd (2nd leg) Horoya AC - US Gorée 2:1
1st(1st leg): 11/02/2017 17:00 2nd (2nd leg): 19/02/2017 17:00 Winner: Horoya AC
1st(1st leg) Ngaya Club de Mdé - Young Africans 1:5
2nd (2nd leg) Young Africans - Ngaya Club de Mdé 1:1
1st(1st leg): 12/02/2017 12:00 2nd (2nd leg): 18/02/2017 13:00 Winner: Young Africans
1st(1st leg) Wa All Stars FC - Al Ahly Tripolis 1:3
2nd (2nd leg) Al Ahly Tripolis - Wa All Stars FC 2:0
1st(1st leg): 12/02/2017 14:00 2nd (2nd leg): 19/02/2017 13:30 Winner: Al Ahly Tripolis
1st(1st leg) Coton Sport Garoua - Atlabara FC 2:0
2nd (2nd leg) Atlabara FC - Coton Sport Garoua 1:4
1st(1st leg): 12/02/2017 14:30 2nd (2nd leg): 18/02/2017 13:30 Winner: Coton Sport Garoua
1st(1st leg) AC Léopards - UMS de Loum 1:0
2nd (2nd leg) UMS de Loum - AC Léopards 2:1
1st(1st leg): 12/02/2017 14:30 2nd (2nd leg): 19/02/2017 14:30 Winner: AC Léopards
1st(1st leg) Barrack Young Controllers - Stade Malien 1:0
2nd (2nd leg) Stade Malien - Barrack Young Controllers 6:7 pso
1st(1st leg): 12/02/2017 16:00 2nd (2nd leg): 19/02/2017 17:00 Winner: Barrack Young Controllers
1st(1st leg) Ports Authority FC - Séwé Sport 1:0
2nd (2nd leg) Séwé Sport - Ports Authority FC 0:0
1st(1st leg): 12/02/2017 16:00 2nd (2nd leg): 19/02/2017 15:30 Winner: Ports Authority FC
1st(1st leg) Sony de Elá Nguema - Al Merrikh SC 0:0
2nd (2nd leg) Al Merrikh SC - Sony de Elá Nguema 4:1
1st(1st leg): 12/02/2017 16:30 2nd (2nd leg): 18/02/2017 17:00 Winner: Al Merrikh SC