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| 1st(1st leg) | Vipers SC | - | Enyimba Aba | 1:0 | ||
| 2nd (2nd leg) | Enyimba Aba | - | Vipers SC | 2:0 | ||
| 1st(1st leg): 12/02/2016 13:00 | 2nd (2nd leg): 28/02/2016 15:00 | Winner: Enyimba Aba | ||||
| 1st(1st leg) | Olympique de Khouribga | - | Gamtel FC | 2:1 | ||
| 2nd (2nd leg) | Gamtel FC | - | Olympique de Khouribga | 1:2 | ||
| 1st(1st leg): 12/02/2016 19:00 | 2nd (2nd leg): 27/02/2016 16:00 | Winner: Olympique de Khouribga | ||||
| 1st(1st leg) | Cercle de Joachim SC | - | Young Africans | 0:1 | ||
| 2nd (2nd leg) | Young Africans | - | Cercle de Joachim SC | 2:0 | ||
| 1st(1st leg): 13/02/2016 11:30 | 2nd (2nd leg): 27/02/2016 13:00 | Winner: Young Africans | ||||
| 1st(1st leg) | Gor Mahia FC | - | CNaPS Sports | 1:2 | ||
| 2nd (2nd leg) | CNaPS Sports | - | Gor Mahia FC | 1:0 | ||
| 1st(1st leg): 13/02/2016 13:00 | 2nd (2nd leg): 27/02/2016 11:30 | Winner: CNaPS Sports | ||||
| 1st(1st leg) | Chicken Inn FC | - | Mamelodi Sundowns | 1:0 | ||
| 2nd (2nd leg) | Mamelodi Sundowns | - | Chicken Inn FC | 2:0 | ||
| 1st(1st leg): 13/02/2016 13:00 | 2nd (2nd leg): 27/02/2016 18:15 | Winner: Mamelodi Sundowns | ||||
| 1st(1st leg) | CRD Libolo | - | Racing de Micomeseng | 5:1 | ||
| 2nd (2nd leg) | Racing de Micomeseng | - | CRD Libolo | 0:4 | ||
| 1st(1st leg): 13/02/2016 14:00 | 2nd (2nd leg): 28/02/2016 14:00 | Winner: CRD Libolo | ||||
| 1st(1st leg) | Mangasport Moanda | - | AS Etoile du Congo | 0:0 | ||
| 2nd (2nd leg) | AS Etoile du Congo | - | Mangasport Moanda | 3:0 | ||
| 1st(1st leg): 13/02/2016 14:30 | 2nd (2nd leg): 28/02/2016 14:30 | Winner: AS Etoile du Congo | ||||
| 1st(1st leg) | Mafunzo | - | AS Vita Club | 0:3 | ||
| 2nd (2nd leg) | AS Vita Club | - | Mafunzo | 1:0 | ||
| 1st(1st leg): 13/02/2016 16:30 | 2nd (2nd leg): 28/02/2016 14:30 | Winner: AS Vita Club | ||||
| 1st(1st leg) | AS Douanes | - | Horoya AC | 0:0 | ||
| 2nd (2nd leg) | Horoya AC | - | AS Douanes | 4:0 | ||
| 1st(1st leg): 13/02/2016 17:00 | 2nd (2nd leg): 28/02/2016 17:00 | Winner: Horoya AC | ||||
| 1st(1st leg) | Stade Malien | - | RC Bobo-Dioulasso | 3:1 | ||
| 2nd (2nd leg) | RC Bobo-Dioulasso | - | Stade Malien | 0:1 | ||
| 1st(1st leg): 13/02/2016 17:00 | 2nd (2nd leg): 28/02/2016 15:30 | Winner: Stade Malien | ||||
| 1st(1st leg) | Centre Chiefs | - | Clube Ferroviário Maputo | 0:3 dec. | ||
| 2nd (2nd leg) | Clube Ferroviário Maputo | - | Centre Chiefs | 3:0 dec. | ||
| 1st(1st leg): 14/02/2016 | 2nd (2nd leg): 28/02/2016 | Winner: Clube Ferroviário Maputo | ||||
| 1st(1st leg) | Volcan Club de Moroni | - | Kaizer Chiefs | 0:4 | ||
| 2nd (2nd leg) | Kaizer Chiefs | - | Volcan Club de Moroni | 3:0 dec. | ||
| 1st(1st leg): 14/02/2016 12:00 | 2nd (2nd leg): 28/02/2016 17:30 | Winner: Kaizer Chiefs | ||||
| 1st(1st leg) | Club Africain | - | AS Tanda | 2:0 | ||
| 2nd (2nd leg) | AS Tanda | - | Club Africain | 0:0 | ||
| 1st(1st leg): 14/02/2016 13:00 | 2nd (2nd leg): 26/02/2016 15:30 | Winner: Club Africain | ||||
| 1st(1st leg) | St. George SC | - | St. Michel United FC | 3:0 | ||
| 2nd (2nd leg) | St. Michel United FC | - | St. George SC | 1:1 | ||
| 1st(1st leg): 14/02/2016 13:00 | 2nd (2nd leg): 27/02/2016 12:30 | Winner: St. George SC | ||||
| 1st(1st leg) | ZESCO United | - | Al Ghazal FC | 2:0 | ||
| 2nd (2nd leg) | Al Ghazal FC | - | ZESCO United | 0:1 | ||
| 1st(1st leg): 14/02/2016 13:00 | 2nd (2nd leg): 26/02/2016 13:30 | Winner: ZESCO United | ||||
| 1st(1st leg) | Mbabane Swallows | - | APR FC | 1:0 | ||
| 2nd (2nd leg) | APR FC | - | Mbabane Swallows | 4:1 | ||
| 1st(1st leg): 14/02/2016 13:30 | 2nd (2nd leg): 27/02/2016 13:30 | Winner: APR FC | ||||
| 1st(1st leg) | Lioli | - | Vital'O | 1:2 | ||
| 2nd (2nd leg) | Vital'O | - | Lioli | 0:1 | ||
| 1st(1st leg): 14/02/2016 14:00 | 2nd (2nd leg): 28/02/2016 13:00 | Winner: Vital'O | ||||
| 1st(1st leg) | AS Coton Chad | - | ASEC Mimosas | 0:1 | ||
| 2nd (2nd leg) | ASEC Mimosas | - | AS Coton Chad | 0:0 | ||
| 1st(1st leg): 14/02/2016 14:00 | 2nd (2nd leg): 28/02/2016 15:30 | Winner: ASEC Mimosas | ||||
| 1st(1st leg) | Warri Wolves | - | Sporting Praia Cruz | 3:0 dec. | ||
| 2nd (2nd leg) | Sporting Praia Cruz | - | Warri Wolves | 0:3 dec. | ||
| 1st(1st leg): 14/02/2016 15:00 | 2nd (2nd leg): 28/02/2016 | Winner: Warri Wolves | ||||
| 1st(1st leg) | Ashanti Gold | - | MO Béjaïa | 1:0 | ||
| 2nd (2nd leg) | MO Béjaïa | - | Ashanti Gold | 3:1 | ||
| 1st(1st leg): 14/02/2016 15:00 | 2nd (2nd leg): 28/02/2016 17:00 | Winner: MO Béjaïa | ||||
| 1st(1st leg) | Onze Créateurs de Niaréla | - | Al Ahly Tripolis | 1:2 | ||
| 2nd (2nd leg) | Al Ahly Tripolis | - | Onze Créateurs de Niaréla | 0:0 | ||
| 1st(1st leg): 14/02/2016 16:00 | 2nd (2nd leg): 26/02/2016 13:00 | Winner: Al Ahly Tripolis | ||||
| 1st(1st leg) | Nimba United | - | AS Matelots | 1:3 | ||
| 2nd (2nd leg) | AS Matelots | - | Nimba United | 1:0 | ||
| 1st(1st leg): 14/02/2016 16:00 | 2nd (2nd leg): 28/02/2016 14:30 | Winner: AS Matelots | ||||
| 1st(1st leg) | Wydad AC | - | AS Douanes | 2:0 | ||
| 2nd (2nd leg) | AS Douanes | - | Wydad AC | 2:1 | ||
| 1st(1st leg): 14/02/2016 19:30 | 2nd (2nd leg): 06/03/2016 | Winner: Wydad AC | ||||
