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| 1st(1st leg) | Fluminense RJ | - | Confiança - SE | 2:0 (0:0) | ||
| 2nd (2nd leg) | Confiança - SE | - | Fluminense RJ | 0:4 (0:1) | ||
| 1st(1st leg): 02/12/2020 18:00 | 2nd (2nd leg): 10/12/2020 18:00 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Brasil de Pelotas - RS | - | Atlético Mineiro | 0:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | Brasil de Pelotas - RS | 2:1 (1:0) | ||
| 1st(1st leg): 02/12/2020 18:00 | 2nd (2nd leg): 09/12/2020 20:00 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | São Paulo FC | - | CR Brasil - AL | 1:0 (1:0) | ||
| 2nd (2nd leg) | CR Brasil - AL | - | São Paulo FC | 1:3 (1:1) | ||
| 1st(1st leg): 02/12/2020 18:00 | 2nd (2nd leg): 10/12/2020 18:00 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Jacuipense - BA | - | Palmeiras | 0:2 (0:0) | ||
| 2nd (2nd leg) | Palmeiras | - | Jacuipense - BA | 3:0 (3:0) | ||
| 1st(1st leg): 02/12/2020 18:00 | 2nd (2nd leg): 09/12/2020 18:00 | Winner: Palmeiras | ||||
| 1st(1st leg) | Sport Recife - PE | - | Londrina - PR | 3:0 (2:0) | ||
| 2nd (2nd leg) | Londrina - PR | - | Sport Recife - PE | 1:4 (1:3) | ||
| 1st(1st leg): 02/12/2020 23:30 | 2nd (2nd leg): 09/12/2020 19:00 | Winner: Sport Recife - PE | ||||
| 1st(1st leg) | Flamengo RJ | - | Maranhão - MA | 8:0 (4:0) | ||
| 2nd (2nd leg) | Maranhão - MA | - | Flamengo RJ | 3:4 (0:0) | ||
| 1st(1st leg): 03/12/2020 18:00 | 2nd (2nd leg): 10/12/2020 18:30 | Winner: Flamengo RJ | ||||
| 1st(1st leg) | Athletico Paranaense | - | Ceará - CE | 6:1 (1:1) | ||
| 2nd (2nd leg) | Ceará - CE | - | Athletico Paranaense | 1:1 (1:1) | ||
| 1st(1st leg): 03/12/2020 20:00 | 2nd (2nd leg): 10/12/2020 18:00 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Grémio - MS | - | River - PI | 0:3 (0:1) | ||
| 2nd (2nd leg) | River - PI | - | Grémio - MS | 5:0 (3:0) | ||
| 1st(1st leg): 05/12/2020 19:00 | 2nd (2nd leg): 13/12/2020 22:30 | Winner: River - PI | ||||
