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| 1st(1st leg) | América - RN | - | Itabaiana - SE | 1:1 (1:1) | ||
| 2nd (2nd leg) | Itabaiana - SE | - | América - RN | 0:2 (0:1) | ||
| 1st(1st leg): 11/09/2021 19:00 | 2nd (2nd leg): 19/09/2021 20:00 | Winner: América - RN | ||||
| 1st(1st leg) | Atlético Cearense - CE | - | Juazeirense - BA | 1:1 (1:0) | ||
| 2nd (2nd leg) | Juazeirense - BA | - | Atlético Cearense - CE | 3:5 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 11/09/2021 19:00 | 2nd (2nd leg): 18/09/2021 20:00 | Winner: Atlético Cearense - CE | ||||
| 1st(1st leg) | Bangu - RJ | - | Joinville - SC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Joinville - SC | - | Bangu - RJ | 4:3 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 11/09/2021 19:00 | 2nd (2nd leg): 18/09/2021 19:00 | Winner: Joinville - SC | ||||
| 1st(1st leg) | Caldense - MG | - | Aparecidense - GO | 1:0 (1:0) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Caldense - MG | 3:1 (2:1) | ||
| 1st(1st leg): 11/09/2021 20:00 | 2nd (2nd leg): 17/09/2021 20:00 | Winner: Aparecidense - GO | ||||
| 1st(1st leg) | Esportivo - RS | - | Santo André - SP | 0:1 (0:1) | ||
| 2nd (2nd leg) | Santo André - SP | - | Esportivo - RS | 4:5 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 11/09/2021 20:00 | 2nd (2nd leg): 18/09/2021 19:00 | Winner: Esportivo - RS | ||||
| 1st(1st leg) | União Rondonópolis - MT | - | Boa Esporte - MG | 2:0 (1:0) | ||
| 2nd (2nd leg) | Boa Esporte - MG | - | União Rondonópolis - MT | 1:1 (1:1) | ||
| 1st(1st leg): 11/09/2021 20:00 | 2nd (2nd leg): 18/09/2021 21:00 | Winner: União Rondonópolis - MT | ||||
| 1st(1st leg) | Brasiliense - DF | - | Ferroviária - SP | 0:0 (0:0) | ||
| 2nd (2nd leg) | Ferroviária - SP | - | Brasiliense - DF | 1:0 (0:0) | ||
| 1st(1st leg): 12/09/2021 19:00 | 2nd (2nd leg): 18/09/2021 21:00 | Winner: Ferroviária - SP | ||||
| 1st(1st leg) | S.E.R. Caxias - RS | - | Portuguesa - SP | 1:0 (0:0) | ||
| 2nd (2nd leg) | Portuguesa - SP | - | S.E.R. Caxias - RS | 1:4 (0:0, 1:0, 1:0) pso | ||
| 1st(1st leg): 12/09/2021 19:00 | 2nd (2nd leg): 18/09/2021 20:00 | Winner: S.E.R. Caxias - RS | ||||
| 1st(1st leg) | Moto Club - MA | - | Castanhal - PA | 2:0 (2:0) | ||
| 2nd (2nd leg) | Castanhal - PA | - | Moto Club - MA | 1:2 (0:0) | ||
| 1st(1st leg): 12/09/2021 19:30 | 2nd (2nd leg): 19/09/2021 19:00 | Winner: Moto Club - MA | ||||
| 1st(1st leg) | Cianorte - PR | - | Cascavel FC - PR | 0:0 (0:0) | ||
| 2nd (2nd leg) | Cascavel FC - PR | - | Cianorte - PR | 0:3 (0:2) | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 18/09/2021 20:00 | Winner: Cianorte - PR | ||||
| 1st(1st leg) | Retrô - PE | - | ABC - RN | 1:1 (0:0) | ||
| 2nd (2nd leg) | ABC - RN | - | Retrô - PE | 3:2 (1:0) | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 19/09/2021 20:00 | Winner: ABC - RN | ||||
| 1st(1st leg) | Paragominas - PA | - | São Raimundo - RR | 1:0 (0:0) | ||
| 2nd (2nd leg) | São Raimundo - RR | - | Paragominas - PA | 1:2 (0:0) | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 19/09/2021 21:00 | Winner: Paragominas - PA | ||||
| 1st(1st leg) | Penarol - AM | - | 4 de Julho - PI | 1:0 (0:0) | ||
| 2nd (2nd leg) | 4 de Julho - PI | - | Penarol - AM | 3:0 (1:0) | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 18/09/2021 20:00 | Winner: 4 de Julho - PI | ||||
| 1st(1st leg) | Sergipe - SE | - | Campinense - PB | 2:2 (0:2) | ||
| 2nd (2nd leg) | Campinense - PB | - | Sergipe - SE | 4:2 (0:0, 0:0, 0:0) pso | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 18/09/2021 19:00 | Winner: Campinense - PB | ||||
| 1st(1st leg) | Uberlândia - MG | - | Nova Mutum - MT | 1:1 (0:0) | ||
| 2nd (2nd leg) | Nova Mutum - MT | - | Uberlândia - MG | 0:2 (0:0) | ||
| 1st(1st leg): 12/09/2021 20:00 | 2nd (2nd leg): 19/09/2021 20:00 | Winner: Uberlândia - MG | ||||
| 1st(1st leg) | Galvez - AC | - | Guarany de Sobral - CE | 0:0 (0:0) | ||
| 2nd (2nd leg) | Guarany de Sobral - CE | - | Galvez - AC | 2:0 (0:0) | ||
| 1st(1st leg): 13/09/2021 21:00 | 2nd (2nd leg): 20/09/2021 19:00 | Winner: Guarany de Sobral - CE | ||||
