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| 1st(1st leg) | Atlético Cearense - CE | - | Campinense - PB | 1:1 (0:0) | ||
| 2nd (2nd leg) | Campinense - PB | - | Atlético Cearense - CE | 3:1 (1:1) | ||
| 1st(1st leg): 23/10/2021 19:00 | 2nd (2nd leg): 30/10/2021 20:00 | Winner: Campinense - PB | ||||
| 1st(1st leg) | Aparecidense - GO | - | ABC - RN | 4:2 (1:1) | ||
| 2nd (2nd leg) | ABC - RN | - | Aparecidense - GO | 1:0 (1:0) | ||
| 1st(1st leg): 24/10/2021 20:00 | 2nd (2nd leg): 31/10/2021 19:00 | Winner: Aparecidense - GO | ||||
