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| 1st(1st leg) | Atlético Mineiro | - | Fortaleza - CE | 4:0 (3:0) | ||
| 2nd (2nd leg) | Fortaleza - CE | - | Atlético Mineiro | 1:2 (0:0) | ||
| 1st(1st leg): 21/10/2021 01:30 | 2nd (2nd leg): 28/10/2021 01:30 | Winner: Atlético Mineiro | ||||
| 1st(1st leg) | Athletico Paranaense | - | Flamengo RJ | 2:2 (0:1) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Athletico Paranaense | 0:3 (0:2) | ||
| 1st(1st leg): 21/10/2021 01:30 | 2nd (2nd leg): 28/10/2021 01:30 | Winner: Athletico Paranaense | ||||
