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| 1st(1st leg) | CA Bragantino | - | Avaí - SC | 1:0 (0:0) | ||
| 2nd (2nd leg) | Avaí - SC | - | CA Bragantino | 1:1 (0:0) | ||
| 1st(1st leg): 04/05/2016 01:30 | 2nd (2nd leg): 11/05/2016 01:30 | Winner: CA Bragantino | ||||
| 1st(1st leg) | Ferroviária - SP | - | Fluminense RJ | 3:3 (2:2) | ||
| 2nd (2nd leg) | Fluminense RJ | - | Ferroviária - SP | 3:0 (3:0) | ||
| 1st(1st leg): 04/05/2016 23:30 | 2nd (2nd leg): 13/05/2016 01:30 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Fortaleza - CE | - | Flamengo RJ | 2:1 (1:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Fortaleza - CE | 1:2 (0:1) | ||
| 1st(1st leg): 05/05/2016 01:45 | 2nd (2nd leg): 19/05/2016 01:45 | Winner: Fortaleza - CE | ||||
| 1st(1st leg) | Genus - RO | - | Ponte Preta | 0:1 (0:0) | ||
| 2nd (2nd leg) | Ponte Preta | - | Genus - RO | 3:0 (1:0) | ||
| 1st(1st leg): 06/05/2016 01:30 | 2nd (2nd leg): 13/05/2016 01:30 | Winner: Ponte Preta | ||||
| 1st(1st leg) | Londrina - PR | - | Cruzeiro | 0:2 (0:2) | ||
| 2nd (2nd leg) | Cruzeiro | - | Londrina - PR | dnp | ||
| 1st(1st leg): 11/05/2016 01:30 | 2nd (2nd leg): 18/05/2016 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Galvez - AC | - | Santos FC | 0:3 (0:2) | ||
| 2nd (2nd leg) | Santos FC | - | Galvez - AC | dnp | ||
| 1st(1st leg): 11/05/2016 23:30 | 2nd (2nd leg): 19/05/2016 | Winner: Santos FC | ||||
| 1st(1st leg) | Paraná Clube | - | Chapecoense | 2:1 (1:1) | ||
| 2nd (2nd leg) | Chapecoense | - | Paraná Clube | 2:0 (1:0) | ||
| 1st(1st leg): 11/05/2016 23:30 | 2nd (2nd leg): 18/05/2016 23:30 | Winner: Chapecoense | ||||
| 1st(1st leg) | Sampaio Corrêa - MA | - | Figueirense - SC | 1:2 (0:0) | ||
| 2nd (2nd leg) | Figueirense - SC | - | Sampaio Corrêa - MA | 1:0 (1:0) | ||
| 1st(1st leg): 11/05/2016 23:30 | 2nd (2nd leg): 06/07/2016 23:30 | Winner: Figueirense - SC | ||||
| 1st(1st leg) | Juventude - RS | - | Coritiba - PR | 1:0 (1:0) | ||
| 2nd (2nd leg) | Coritiba - PR | - | Juventude - RS | 2:2 (1:0) | ||
| 1st(1st leg): 11/05/2016 23:30 | 2nd (2nd leg): 19/05/2016 23:15 | Winner: Juventude - RS | ||||
| 1st(1st leg) | Joinville - SC | - | Ceará - CE | 0:1 (0:1) | ||
| 2nd (2nd leg) | Ceará - CE | - | Joinville - SC | 1:0 (0:0) | ||
| 1st(1st leg): 11/05/2016 23:30 | 2nd (2nd leg): 17/05/2016 23:15 | Winner: Ceará - CE | ||||
| 1st(1st leg) | River - PI | - | Botafogo - PB | 0:1 (0:0) | ||
| 2nd (2nd leg) | Botafogo - PB | - | River - PI | 1:0 (0:0) | ||
| 1st(1st leg): 12/05/2016 00:30 | 2nd (2nd leg): 19/05/2016 00:30 | Winner: Botafogo - PB | ||||
| 1st(1st leg) | Ypiranga - RS | - | Aparecidense - GO | 3:1 (1:1) | ||
| 2nd (2nd leg) | Aparecidense - GO | - | Ypiranga - RS | 2:1 (1:0) | ||
| 1st(1st leg): 12/05/2016 00:30 | 2nd (2nd leg): 20/05/2016 01:30 | Winner: Ypiranga - RS | ||||
| 1st(1st leg) | Dom Bosco - MT | - | Athletico Paranaense | 2:2 (0:1) | ||
| 2nd (2nd leg) | Athletico Paranaense | - | Dom Bosco - MT | 5:0 (3:0) | ||
| 1st(1st leg): 12/05/2016 01:30 | 2nd (2nd leg): 18/05/2016 23:30 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | CR Brasil - AL | - | Vasco da Gama - RJ | 0:1 (0:1) | ||
| 2nd (2nd leg) | Vasco da Gama - RJ | - | CR Brasil - AL | 1:1 (0:1) | ||
| 1st(1st leg): 12/05/2016 01:45 | 2nd (2nd leg): 18/05/2016 23:30 | Winner: Vasco da Gama - RJ | ||||
| 1st(1st leg) | Vitória da Conquista - BA | - | Santa Cruz - PE | 0:2 (0:0) | ||
| 2nd (2nd leg) | Santa Cruz - PE | - | Vitória da Conquista - BA | dnp | ||
| 1st(1st leg): 12/05/2016 01:45 | 2nd (2nd leg): 19/05/2016 | Winner: Santa Cruz - PE | ||||
| 1st(1st leg) | América - MG | - | Bahia - BA | 0:0 (0:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | América - MG | 0:1 (0:0) | ||
| 1st(1st leg): 12/05/2016 01:45 | 2nd (2nd leg): 19/05/2016 01:45 | Winner: América - MG | ||||
| 1st(1st leg) | Portuguesa - SP | - | Vitória - BA | 0:0 (0:0) | ||
| 2nd (2nd leg) | Vitória - BA | - | Portuguesa - SP | 3:1 (1:1) | ||
| 1st(1st leg): 12/05/2016 01:45 | 2nd (2nd leg): 20/05/2016 01:30 | Winner: Vitória - BA | ||||
| 1st(1st leg) | Juazeirense - BA | - | Botafogo - RJ | 1:2 (0:1) | ||
| 2nd (2nd leg) | Botafogo - RJ | - | Juazeirense - BA | 1:0 (0:0) | ||
| 1st(1st leg): 12/05/2016 23:15 | 2nd (2nd leg): 20/05/2016 01:30 | Winner: Botafogo - RJ | ||||
| 1st(1st leg) | Operário Ferroviário - PR | - | Paysandu - PA | 1:0 (0:0) | ||
| 2nd (2nd leg) | Paysandu - PA | - | Operário Ferroviário - PR | 2:0 (2:0) | ||
| 1st(1st leg): 17/05/2016 23:15 | 2nd (2nd leg): 06/07/2016 23:30 | Winner: Paysandu - PA | ||||
| 1st(1st leg) | Gama - DF | - | ABC - RN | 1:1 (0:1) | ||
| 2nd (2nd leg) | ABC - RN | - | Gama - DF | 1:4 (1:0, 1:1) pso | ||
| 1st(1st leg): 01/06/2016 23:30 | 2nd (2nd leg): 16/06/2016 00:30 | Winner: Gama - DF | ||||
